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非出血性损伤对大鼠倾斜时心血管反应的影响。

Effects of non-haemorrhagic injury on the cardiovascular response to tilting in the rat.

作者信息

Little R A

出版信息

Br J Exp Pathol. 1979 Jun;60(3):309-13.

PMID:475977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041455/
Abstract

In the unanaesthetized uninjured rat a head-up tilt elicited a pressor response, the magnitude of which was directly related to the angle of tilt. The pressor response was reduced by a 4 h period of bilateral hind-limb ischaemia and by a non-fatal scald, although the slope of the regression line relating percentage rise in mean arterial blood pressure to the angle of tilt was unaltered. The degree of impairment of the response was directly related to the severity of the injury. In the uninjured rat there was a sigmoid relationship between the angle of tilt and the mean heart rate during the tilt. No relationship could be demonstrated between angle of tilt and heart rate in the injured rats.

摘要

在未麻醉、未受伤的大鼠中,头高位倾斜会引发升压反应,其幅度与倾斜角度直接相关。双侧后肢缺血4小时和非致命性烫伤会使升压反应减弱,尽管平均动脉血压升高百分比与倾斜角度的回归线斜率未改变。反应受损程度与损伤严重程度直接相关。在未受伤的大鼠中,倾斜角度与倾斜期间的平均心率之间呈S形关系。在受伤的大鼠中,倾斜角度与心率之间未显示出相关性。

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引用本文的文献

1
Changes in cardiac output and its distribution after non-haemorrhagic injury in the rat.大鼠非出血性损伤后心输出量及其分布的变化。
Br J Exp Pathol. 1980 Aug;61(4):421-8.

本文引用的文献

1
Effect of gravity on the blood pressure of the cat.重力对猫血压的影响。
J Physiol. 1940 Mar 14;98(1):79-96. doi: 10.1113/jphysiol.1940.sp003835.
2
The importance of the brain in the endocrine response to injury.大脑在损伤内分泌反应中的重要性。
Ann Surg. 1959 Oct;150(4):697-712. doi: 10.1097/00000658-195910000-00013.
3
Studies on the mechanism of shock: the influence of environment on the changes in oxygen consumption, tissue temperature and blood flow produced by limb ischaemia.休克机制的研究:环境对肢体缺血所致氧耗、组织温度及血流变化的影响。
Br J Exp Pathol. 1958 Jun;39(3):251-77.
4
Effects of depth of anesthesia on behavior of peripheral vascular bed.麻醉深度对外周血管床行为的影响。
Anesthesiology. 1953 May;14(3):245-54. doi: 10.1097/00000542-195305000-00004.
5
Accidental hypothermia in walkers, climbers, and campers: report to the Medical Commission on Accident Prevention.步行者、登山者和露营者的意外低体温症:提交给事故预防医学委员会的报告
Br Med J. 1966 Jan 15;1(5480):123-9. doi: 10.1136/bmj.1.5480.123.
6
Effects of anesthesia and sleep on circulatory response to carotid sinus nerve stimulation.麻醉和睡眠对颈动脉窦神经刺激的循环反应的影响。
Am J Physiol. 1971 May;220(5):1249-55. doi: 10.1152/ajplegacy.1971.220.5.1249.
7
The effect of hypovolemic hypotension on extra- and intracellular acid-base parameters and energy metabolites in the rat brain.
Acta Physiol Scand. 1970 May;79(1):114-24. doi: 10.1111/j.1748-1716.1970.tb04707.x.
8
Cardiovascular responses to tilting in tetraplegic man.四肢瘫痪患者倾斜时的心血管反应。
J Physiol. 1971 Jun;215(2):411-31. doi: 10.1113/jphysiol.1971.sp009477.
9
Reduced cardiovascular responsiveness to hypothalamic stimulation during urethane and amobarbital anesthesia.在氨基甲酸乙酯和异戊巴比妥麻醉期间,心血管系统对下丘脑刺激的反应性降低。
Pharmacology. 1973;10(3):143-51. doi: 10.1159/000136434.
10
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Acta Physiol Scand. 1972 Dec;86(4):515-27. doi: 10.1111/j.1748-1716.1972.tb05353.x.