Ng A B, Atkin N B
Br J Cancer. 1973 Oct;28(4):322-31. doi: 10.1038/bjc.1973.155.
Based on the evaluation of 362 cases of squamous cell carcinoma of the uterine cervix, the distribution of the tumours in relation to their modified Broders' grade, histological cell type as proposed by Wentz and Reagan, and the clinical stage of disease was evaluated. The morphological characteristics of the 3 cell types-large cell non-keratinizing, keratinizing, and small cell cancers-were described. The 5 year survival in relation to Broders' grade, cell type, extent and DNA values of the malignant cells were evaluated and compared. Broders' grading system was not useful in predicting the biological behaviour of cervical squamous cancer. The histological cell type and extent of the tumour were important factors in prognosis. The 5 year survival for large cell cancer was 51·8%, keratinizing cancer 34·7% and small cell cancer 10·0%. The 5 year survival was 63·3% for stage I neoplasms, 52·9% for stage II neoplasms, 30·7% for stage III neoplasms and 15·0% for stage IV neoplasms. When the DNA values of neoplastic cells were considered in relation to cell type and extent of disease, the biological behaviour of cervical squamous cell cancers was determined more accurately. The 5 year survival of women with cervical cancer in which the DNA values of the neoplastic cells exceeded 155 was more favourable than those with DNA values of less than 155. This difference in 5 year survival was evident for comparable cell type and clinical stage of disease.
基于对362例子宫颈鳞状细胞癌的评估，对肿瘤的分布与改良的布罗德斯分级、温茨和里根提出的组织学细胞类型以及疾病临床分期的关系进行了评估。描述了3种细胞类型（大细胞非角化型、角化型和小细胞癌）的形态学特征。评估并比较了与布罗德斯分级、细胞类型、恶性细胞范围和DNA值相关的5年生存率。布罗德斯分级系统在预测宫颈鳞状癌的生物学行为方面并无用处。肿瘤的组织学细胞类型和范围是预后的重要因素。大细胞癌的5年生存率为51.8%，角化型癌为34.7%，小细胞癌为10.0%。I期肿瘤的5年生存率为63.3%，II期肿瘤为52.9%，III期肿瘤为30.7%，IV期肿瘤为15.0%。当考虑肿瘤细胞的DNA值与细胞类型和疾病范围的关系时，能更准确地确定宫颈鳞状细胞癌的生物学行为。肿瘤细胞DNA值超过155的宫颈癌女性的5年生存率高于DNA值低于155的女性。在可比的细胞类型和疾病临床分期中，5年生存率的这种差异很明显。
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