清醒大鼠口服硫酸钠后无机硫酸盐的吸收、血清水平及尿排泄情况。

Absorption, serum levels and urinary excretion of inorganic sulfate after oral administration of sodium sulfate in the conscious rat.

作者信息

Krijgsheld K R, Frankena H, Scholtens E, Zweens J, Mulder G J

出版信息

Biochim Biophys Acta. 1979 Sep 3;586(3):492-500. doi: 10.1016/0304-4165(79)90039-4.

Abstract

The absorption of inorganic sulfate after ingestion was investigated in rats. After oral administration of Na235SO4, 35S radioactivity was measurable in plasma already after 15 min and its plasma concentration reached a peak after about 1.5--2 h. The 35S-radioactivity excreted in urine during 24 h after ingestion of Na235SO4 together with varying amounts of unlabelled Na2SO4 (0.25--5.0 mmol Na2SO4 per rat) indicated an almost complete absorption of inorganic sulfate from the gastrointestinal tract. Determination of the inorganic sulfate concentration in rat serum 2 h after oral administration of 5.0 mmol Na2SO4 revealed a three-fold increase in serum sulfate concentration. The data suggest a rapid and almost complete absorption of inorganic sulfate after oral administration in the rat. Its importance in relation to the sulfate availability for sulfate conjugation of drugs is discussed.

摘要

对大鼠摄入无机硫酸盐后的吸收情况进行了研究。口服Na₂³⁵SO₄后，15分钟后血浆中即可检测到³⁵S放射性，其血浆浓度在约1.5 - 2小时后达到峰值。摄入Na₂³⁵SO₄后24小时内随不同量未标记的Na₂SO₄（每只大鼠0.25 - 5.0 mmol Na₂SO₄）经尿液排出的³⁵S放射性表明，无机硫酸盐几乎完全从胃肠道吸收。口服5.0 mmol Na₂SO₄ 2小时后测定大鼠血清中的无机硫酸盐浓度，结果显示血清硫酸盐浓度增加了三倍。数据表明，大鼠口服无机硫酸盐后吸收迅速且几乎完全。文中讨论了其与药物硫酸结合反应中硫酸盐可利用性的关系。