黄杆菌属细菌中的类胡萝卜素生物合成：八氢番茄红素去饱和生成番茄红素、玉红黄质和玉米黄质过程中氢消除的立体化学
Carotenoid biosynthesis in a Flavobacterium sp.: stereochemistry of hydrogen elimination in the desaturation of phytoene to lycopene, rubixanthin and zeaxanthin.
作者信息
McDermott J C, Britton G, Goodwin T W
出版信息
Biochem J. 1973 Aug;134(4):1115-7. doi: 10.1042/bj1341115.
Abstract
[2-(14)C,(2R)-2-(3)H(1)]- and [2-(14)C,(2S)-2-(3)H(1)]-Mevalonates were rapidly incorporated into phytoene, lycopene, rubixanthin and zeaxanthin in a Flavobacterium system obtained by disruption of the bacterial cells by shaking with glass beads. Four hydrogen atoms arising from the 2-pro-S-hydrogen atoms of mevalonate were lost in the desaturation of phytoene to lycopene, rubixanthin and zeaxanthin. The desaturation of phytoene involves trans-elimination of hydrogen in the introduction of the double bonds at C-7, C-11, C-7' and C-11'.
摘要
[2-(14)C，(2R)-2-(3)H(1)]-和[2-(14)C，(2S)-2-(3)H(1)]-甲羟戊酸在通过用玻璃珠振荡破坏细菌细胞而获得的黄杆菌系统中迅速掺入八氢番茄红素、番茄红素、玉红黄质和玉米黄质中。甲羟戊酸的2-前手性-S-氢原子产生的四个氢原子在八氢番茄红素脱氢生成番茄红素、玉红黄质和玉米黄质的过程中丢失。八氢番茄红素的脱氢涉及在C-7、C-11、C-7'和C-11'处引入双键时氢的反式消除。
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