胆固醇生物合成的研究。18. 甲羟戊酸还原酶的立体特异性及不对称标记法呢基焦磷酸的生物合成。 - Suppr

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Studies on the biosynthesis of cholesterol. 18. The stereospecificity of mevaldate reductase and the biosynthesis of asymmetrically labelled farnesyl pyrophosphate.

作者信息

Donninger C, Popják G

出版信息

Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):465-91. doi: 10.1098/rspb.1966.0003.

DOI:10.1098/rspb.1966.0003

PMID:4379290

Abstract

摘要

相似文献

Studies on the biosynthesis of cholesterol. 18. The stereospecificity of mevaldate reductase and the biosynthesis of asymmetrically labelled farnesyl pyrophosphate.胆固醇生物合成的研究。18. 甲羟戊酸还原酶的立体特异性及不对称标记法呢基焦磷酸的生物合成。

Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):465-91. doi: 10.1098/rspb.1966.0003.

Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate.胆固醇生物合成的研究。XX。5-焦磷酸甲羟戊酸脱羧反应的立体化学过程以及法呢基焦磷酸生物合成中碳-碳键的形成。

J Biol Chem. 1966 Sep 10;241(17):3970-87.

Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.鲨烯合酶抑制剂对胆固醇合成的抑制作用在体外不会诱发肌毒性。

Toxicol Appl Pharmacol. 1997 Jul;145(1):91-8. doi: 10.1006/taap.1997.8131.

Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule.

Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):437-64.

Enzymic formation of squalene homologs from farnesyl Pyrophosphate homologs.由法呢基焦磷酸酯同系物通过酶促反应形成角鲨烯同系物。

J Am Chem Soc. 1972 Jan 12;94(1):307-9. doi: 10.1021/ja00756a070.

[Utilization of farnesyl pyrophosphate by rat liver microsomes in the absence of nicotinamide adenine dinucleotides].[大鼠肝微粒体在无烟酰胺腺嘌呤二核苷酸情况下对法尼基焦磷酸的利用]

Arch Int Physiol Biochim. 1964 Mar;72(2):321-3.

Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells.法尼醇用于哺乳动物细胞中的蛋白质异戊二烯化和胆固醇的生物合成。

Biochem Biophys Res Commun. 1995 Jun 15;211(2):590-9. doi: 10.1006/bbrc.1995.1854.

[BIOSYNTHESIS OF FARNESOL PYROPHOSPHATE AND SQUALENE FROM 2-C14-MEVALONIC ACID BY CELL FRACTIONS OF ADRENAL HOMOGENATE].[肾上腺匀浆细胞组分由2-C¹⁴-甲羟戊酸合成法呢醇焦磷酸酯和角鲨烯]

Bull Soc Chim Biol (Paris). 1965;47:359-61.

Properties of farnesyl pyrophosphate synthetase of pig liver.猪肝法尼基焦磷酸合成酶的特性

Arch Biochem Biophys. 1965 Jun;110(3):611-21. doi: 10.1016/0003-9861(65)90457-1.

Biosynthesis of phytoene from isopentenyl and farnesyl pyrophosphates by a partially purified tomato enzyme system.利用部分纯化的番茄酶系统，由异戊烯基焦磷酸和法呢基焦磷酸生物合成八氢番茄红素。

Arch Biochem Biophys. 1967 Mar;119(1):209-19. doi: 10.1016/0003-9861(67)90448-1.

引用本文的文献

Substrate stereochemistry in squalene biosynthesis: The first Ciba medal lecture.角鲨烯生物合成中的底物立体化学：首届汽巴奖章讲座

Biochem J. 1966 Dec;101(3):553.b4-568.

The stereospecific biosynthesis of phytoene and polyunsaturated carotenes.八氢番茄红素和多不饱和类胡萝卜素的立体专一性生物合成。

Biochem J. 1967 Sep;104(3):767-77. doi: 10.1042/bj1040767.

Characterization of the hexahydropolyprenols of Aspergillus fumigatus Fresenius.烟曲霉弗里斯菌六氢聚戊烯醇的特性研究

Biochem J. 1967 Feb;102(2):443-55. doi: 10.1042/bj1020443.

Incorporation of (2-14C, (5r)-5-3H1) mevalonic acid into cholesterol by a rat liver homogenate and into beta-sitosterol and 28-isofucosterol by larix decidua leaves.大鼠肝脏匀浆将（2-¹⁴C，（5r）-5-³H¹）甲羟戊酸掺入胆固醇中，落叶松叶片将其掺入β-谷甾醇和28-异岩藻甾醇中。

Biochem J. 1969 Oct;114(4):885-92. doi: 10.1042/bj1140885.

Carotenoid biosynthesis in a Flavobacterium sp.: stereochemistry of hydrogen elimination in the desaturation of phytoene to lycopene, rubixanthin and zeaxanthin.黄杆菌属细菌中的类胡萝卜素生物合成：八氢番茄红素去饱和生成番茄红素、玉红黄质和玉米黄质过程中氢消除的立体化学

Biochem J. 1973 Aug;134(4):1115-7. doi: 10.1042/bj1341115.

Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata.穿心莲组织培养物中可溶性酶催化反,反-和顺,反-法尼醇的生物合成。

Biochem J. 1974 Dec;144(3):585-92. doi: 10.1042/bj1440585.

Some properties and a suggested reclassification of mevaldate reductase.甲羟戊酸还原酶的一些特性及建议的重新分类

Biochem J. 1974 Apr;139(1):205-9. doi: 10.1042/bj1390205.

Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems.对与角鲨烯合成酶和角鲨烯氧化环化酶系统结合的颗粒性酶可能的组织形式进行分析。

Biochem J. 1969 Feb;111(4):445-51. doi: 10.1042/bj1110445.

Artificial substrates for prenyltransferase.异戊烯基转移酶的人工底物。

Biochem J. 1969 Aug;113(5):861-8. doi: 10.1042/bj1130861.

Stereochemistry of phytoene biosynthesis by isolated chloroplasts.离体叶绿体中八氢番茄红素生物合成的立体化学

Biochem J. 1969 Sep;114(3):641-3. doi: 10.1042/bj1140641.

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