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每日重复给予胆碱酯酶抑制剂后大鼠回肠、子宫和输精管对卡巴胆碱和乙酰胆碱的反应

Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor.

作者信息

Foley D J, McPhillips J J

出版信息

Br J Pharmacol. 1973 Jul;48(3):418-25. doi: 10.1111/j.1476-5381.1973.tb08350.x.

DOI:10.1111/j.1476-5381.1973.tb08350.x
PMID:4764290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776119/
Abstract
  1. Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths.2. Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did not exhibit any change in sensitivity to carbachol.3. The sensitivity to acetylcholine was increased in the ileum and vas deferens but not in the uterus.4. Acetylcholinesterase activity was 60-70% inhibited in all three tissues.
摘要

  1. 连续八天每天给大鼠腹腔注射胆碱酯酶抑制剂乙拌磷，会产生轻度至中度中毒症状（震颤、大小便失禁和腹泻），但无死亡情况。

  2. 取自经治疗大鼠的回肠段对卡巴胆碱反应不敏感，但输精管和子宫对卡巴胆碱的敏感性未表现出任何变化。

  3. 回肠和输精管对乙酰胆碱的敏感性增加，但子宫未增加。

  4. 所有三种组织中的乙酰胆碱酯酶活性均被抑制60 - 70%。

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1
Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor.每日重复给予胆碱酯酶抑制剂后大鼠回肠、子宫和输精管对卡巴胆碱和乙酰胆碱的反应
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Paralysis of autonomic ganglia by methonium salts.甲胺盐对自主神经节的麻痹作用。
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Glycerylphosphorylcholine in the male reproductive organs of rats and guinea-pigs.大鼠和豚鼠雄性生殖器官中的甘油磷酸胆碱
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Pharmacol Rev. 1955 Dec;7(4):467-94.