每日重复给予胆碱酯酶抑制剂后大鼠回肠、子宫和输精管对卡巴胆碱和乙酰胆碱的反应
Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor.
作者信息
Foley D J, McPhillips J J
出版信息
Br J Pharmacol. 1973 Jul;48(3):418-25. doi: 10.1111/j.1476-5381.1973.tb08350.x.
Abstract
- Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths.2. Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did not exhibit any change in sensitivity to carbachol.3. The sensitivity to acetylcholine was increased in the ileum and vas deferens but not in the uterus.4. Acetylcholinesterase activity was 60-70% inhibited in all three tissues.
摘要
连续八天每天给大鼠腹腔注射胆碱酯酶抑制剂乙拌磷，会产生轻度至中度中毒症状（震颤、大小便失禁和腹泻），但无死亡情况。
取自经治疗大鼠的回肠段对卡巴胆碱反应不敏感，但输精管和子宫对卡巴胆碱的敏感性未表现出任何变化。
回肠和输精管对乙酰胆碱的敏感性增加，但子宫未增加。
所有三种组织中的乙酰胆碱酯酶活性均被抑制60 - 70%。
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Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor.每日重复给予胆碱酯酶抑制剂后大鼠回肠、子宫和输精管对卡巴胆碱和乙酰胆碱的反应
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
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Br J Pharmacol Chemother. 1951 Mar;6(1):155-68. doi: 10.1111/j.1476-5381.1951.tb00631.x.
3
Pharmacology of organophosphorus cholinesterase inhibitors.有机磷胆碱酯酶抑制剂的药理学
Pharmacol Rev. 1959 Sep;11:567-688.
4
STUDIES ON THE MECHANISM OF ACQUIRED TOLERANCE BY RATS OF 0,0-DIETHYL S-2-(ETHYLTHIO)ETHYL PHOSPHORODITHIOATE (DI-SYSTON).0,0-二乙基-S-2-（乙硫基）乙基二硫代磷酸酯（敌杀磷）对大鼠获得性耐受性机制的研究
Arch Int Pharmacodyn Ther. 1964 Jun 1;149:560-70.
5
HISTOCHEMICAL DISTRIBUTION OF CHOLINESTERASES IN THE TESTIS, EPIDIDYMIS AND VAS DEFERENS OF THE RAT.
Anat Rec. 1964 Feb;148:231-49. doi: 10.1002/ar.1091480213.
6
The fine structure of autonomic nerve endings in smooth muscle of the rat vas deferens.大鼠输精管平滑肌中自主神经末梢的精细结构
J Anat. 1962 Oct;96(Pt 4):427-42.
7
Supersensitivity following "pharmacological denervation".“药理学去神经支配”后的超敏反应
Pharmacol Rev. 1961 Mar;13:17-37.
8
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Q J Exp Physiol Cogn Med Sci. 1959 Jan;44(1):26-34. doi: 10.1113/expphysiol.1959.sp001373.
9
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AMA Arch Ind Health. 1958 Mar;17(3):192-9.
10
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Pharmacol Rev. 1955 Dec;7(4):467-94.
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