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Comparative study of thin-layer chromatographic techniques for separation of digoxin, digitoxin and their main metabolites.

作者信息

Carvalhas M L, Figueira M A

出版信息

J Chromatogr. 1973 Nov 7;86(1):254-60. doi: 10.1016/s0021-9673(01)81267-x.

DOI:10.1016/s0021-9673(01)81267-x
PMID:4765314
Abstract
摘要

相似文献

1
Comparative study of thin-layer chromatographic techniques for separation of digoxin, digitoxin and their main metabolites.用于分离地高辛、洋地黄毒苷及其主要代谢物的薄层色谱技术的比较研究
J Chromatogr. 1973 Nov 7;86(1):254-60. doi: 10.1016/s0021-9673(01)81267-x.
2
Identification of submicrogram amounts of digoxin, digitoxin, and their metabolic products. Isolation by chromatography and preparation of derivatives for assay by electron capture detector.亚微克量地高辛、洋地黄毒苷及其代谢产物的鉴定。通过色谱法分离并制备衍生物以供电子捕获检测器测定。
J Chromatogr. 1972 Jun 28;69(1):157-63. doi: 10.1016/s0021-9673(00)83095-2.
3
Rapid identification and estimation of gitoxin in digitoxin and digoxin tablets by TLC.通过薄层色谱法快速鉴定和估算洋地黄毒苷和地高辛片剂中的吉他洛苷。
J Pharm Sci. 1971 Feb;60(2):298-9. doi: 10.1002/jps.2600600232.
4
A fluorometric determination of myocardial digoxin at autopsy, with identification of digitalis leaf, digitoxin, and gitoxin.尸检时心肌地高辛的荧光测定法，同时鉴定洋地黄叶、洋地黄毒苷和吉他洛苷。
Am J Clin Pathol. 1969 Mar;51(3):347-57. doi: 10.1093/ajcp/51.3.347.
5
The reactivity of derivatives of digoxin and digitoxin as measured by the Na-K-atpase displacement assay and by radioimmunoassay.通过钠钾 - ATP酶置换试验和放射免疫测定法所测得的地高辛和洋地黄毒苷衍生物的反应活性。
J Lab Clin Med. 1975 Apr;85(4):610-20.
6
[Detection and identification of cardioactive glycosides in toxicology].[毒理学中心脏活性苷类的检测与鉴定]
Arch Toxikol. 1969;25(1):27-31.
7
Colorimetric assay of digitoxin and gitoxin in mixtures after thin-layer chromatographic separation.薄层色谱分离后混合物中洋地黄毒苷和吉他洛苷的比色测定
J Chromatogr. 1969 Apr 22;41(1):91-5. doi: 10.1016/0021-9673(64)80100-x.
8
[Spectrophotometric method for the quantitative determination of digitoxin, gitoxin, celanide and digoxin].[地高辛、洋地黄毒苷、毛花苷丙和去乙酰毛花苷定量测定的分光光度法]
Farm Zh. 1971;26(4):28-30.
9
[Separation of heart glycosides, digitoxin and digoxin, from their 20,22-dihydro derivatives by multiple thin layer chromatography on cellulose layers].[通过在纤维素层上进行多次薄层色谱法从其20,22-二氢衍生物中分离强心苷、洋地黄毒苷和地高辛]
J Chromatogr. 1968 May 21;35(1):122-5. doi: 10.1016/s0021-9673(01)82364-5.
10
Detection of digoxin, digitoxin, their cardioactive metabolites and derivatives by high-performance liquid chromatography and high-performance liquid chromatography-radioimmunoassay.通过高效液相色谱法和高效液相色谱-放射免疫分析法检测地高辛、洋地黄毒苷、它们的心脏活性代谢物及衍生物。
J Chromatogr. 1986 Apr 25;377:221-31. doi: 10.1016/s0378-4347(00)80777-x.

引用本文的文献

1
Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.中枢神经系统炎症期间大脑和肝脏中mdr1a表达的下调改变了地高辛的体内处置。
Br J Pharmacol. 2003 May;139(1):35-48. doi: 10.1038/sj.bjp.0705227.
2
Phenobarbital-digitoxin interaction in the guinea pig liver.苯巴比妥与洋地黄毒苷在豚鼠肝脏中的相互作用。
Eur J Drug Metab Pharmacokinet. 1982;7(3):165-71. doi: 10.1007/BF03189562.
3
Effect of quinidine on digoxin bioavailability.
Eur J Clin Pharmacol. 1983;24(1):41-7. doi: 10.1007/BF00613925.
4
The effects of chloroquine and other weak bases on the accumulation and efflux of digoxin and ouabain in HeLa cells.氯喹及其他弱碱对HeLa细胞中地高辛和哇巴因蓄积及外排的影响。
Br J Pharmacol. 1983 Aug;79(4):877-90. doi: 10.1111/j.1476-5381.1983.tb10532.x.