Bresnick E, Meunier P, Lamden M
Cancer Lett. 1979 Jul;7(2-3):121-5. doi: 10.1016/s0304-3835(79)80106-8.
The topical application of the promoter, 12-O-tetradecanoyl-13-acetate, on the shaved backs of mice was attended by a striking increase in the PGE concentration within epidermis as early as 1 h later. This increase peaked at 24 h but the prostaglandin value remained elevated for at least 48 h. PGF, on the other hand, showed only a modest increase in epidermis with a maximum at 12 h. By 48 h, the PGF concentration returned to normal.
将促癌剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯局部涂抹于小鼠背部剃毛区后，早在1小时后，表皮内的前列腺素E（PGE）浓度就显著升高。这种升高在24小时达到峰值，但前列腺素值至少在48小时内一直保持升高。另一方面，前列腺素F（PGF）在表皮中仅出现适度升高，在12小时达到最大值。到48小时时，PGF浓度恢复正常。
