Kumar M S, Chiang T, Deodhar S D
Cancer Res. 1979 Sep;39(9):3515-8.
We studied the effect of thyroxine treatment on tumor growth and metastases resulting from tumor implants on the hind feet of mice in two syngeneic systems. In control, untreated A/Jax mice, tumor Sarcoma 1 at Day 14 after implantation had average tumor weight of 582 +/- 60 (S.D.) mg and showed an incidence of 57% metastases to regional popliteal nodes and 5% metastases to thymus. In contrast, the thyroxine-treated group (40 microgram/mouse s.c., 5 times/week for 1 month) had an average tumor weight of 808 +/- 56 mg (p less than 0.001), and metastases to popliteal nodes and thymus were 90 and 35%, respectively. In another syngeneic tumor system, Lewis fibrosarcoma was implanted in C57BL/6J mice, and the tumor weight and metastatic index (derived from the number and size of the pulmonary tumor foci) were determined at Day 28. Again, the synthetic L-thyroxine treated group showed a significant enhancement tumor growth and metastatic index. The mean tumor weight in the treated group was 385 +/- 26 mg (control, 694 +/- 25 mg; p less than 0.005) and metastatic index was 84 +/- 29 (control, 30 +/- 25; p less than 0.001). Induced hypothyroidism (treatment with 131I, 100 microCi/mouse i.p.) showed the reverse effect on both tumor systems. These results suggest that both tumor systems are dependent on thyroid hormones for their growth and spread.
我们在两个同基因系统中研究了甲状腺素治疗对小鼠后足肿瘤植入所致肿瘤生长和转移的影响。在对照的未治疗的A/Jax小鼠中，植入后第14天的肉瘤1肿瘤平均重量为582±60（标准差）mg，区域腘窝淋巴结转移发生率为57%，胸腺转移发生率为5%。相比之下，甲状腺素治疗组（40微克/小鼠皮下注射，每周5次，共1个月）的肿瘤平均重量为808±56 mg（p<0.001），腘窝淋巴结和胸腺转移率分别为90%和35%。在另一个同基因肿瘤系统中，将Lewis纤维肉瘤植入C57BL/6J小鼠体内，并在第28天测定肿瘤重量和转移指数（由肺肿瘤灶的数量和大小得出）。同样，合成L-甲状腺素治疗组的肿瘤生长和转移指数也显著增强。治疗组的平均肿瘤重量为385±26 mg（对照组为694±25 mg；p<0.005），转移指数为84±29（对照组为30±25；p<0.001）。诱导性甲状腺功能减退（用131I治疗，100微居里/小鼠腹腔注射）对两个肿瘤系统均显示出相反的作用。这些结果表明，两个肿瘤系统的生长和扩散均依赖于甲状腺激素。
