Al-Barwari S E, Potten C S
Cell Tissue Kinet. 1979 May;12(3):281-9. doi: 10.1111/j.1365-2184.1979.tb00150.x.
Skin reactions to various doses of X-rays (300 and 10 kV) and ultraviolet light (u.v.) have been compared using hairless mice. Two regions of epidermis with widely differing cell kinetics and gross structure have been compared. Little evidence could be found to support the idea that the early phases of the reaction are dependent on cell cycle time. The data can be explained by a model based on the assumption that epidermis contains only a small fraction of clonogenic (stem) cells and this fraction may vary in different epidermal regions. X-rays appear to exert their greatest destructive action on these clonogenic cells while u.v. is more indiscriminate in its action, killing both clonogenic and non-clonogenic cells.
使用无毛小鼠比较了不同剂量的X射线（300和10千伏）及紫外线对皮肤的反应。比较了表皮中细胞动力学和总体结构差异很大的两个区域。几乎找不到证据支持反应早期阶段依赖细胞周期时间这一观点。这些数据可以用一个模型来解释，该模型基于这样的假设：表皮仅含有一小部分克隆原性（干细胞）细胞，且这一比例在不同的表皮区域可能有所不同。X射线似乎对这些克隆原性细胞发挥最大的破坏作用，而紫外线的作用则更具随机性，会杀死克隆原性细胞和非克隆原性细胞。
