Blackett N M, Aguado M
Cell Tissue Kinet. 1979 May;12(3):291-8. doi: 10.1111/j.1365-2184.1979.tb00151.x.
Studies are reported of the enhancement of stem cell recovery following whole body irradiation as a result of prior administration of cyclophosphamide. It is shown that the much larger enhancement of regeneration observed for the hosts own surviving stem cells, compared to the regeneration of injected bone marrow stem cells, is due to the different numbers of stem cells initiating the regeneration in conjunction with the time course of stem cell regeneration. The results show that the environmental changes produced by cyclophosphmide greatly enhance haemopoietic recovery even though at the dose used this agent is relatively toxic to stem cells. Furthermore it has been shown that the level of stem cell regeneration is nearly independent of the gamma-ray dose in the range 3-8 gray (300-800 rad). If human bone marrow should respond similarly it follows that regeneration produced by cytotoxic drugs administered prior to radiation embodies a considerable safety factor as far as recovery of the haemopoietic system is concerned.
有研究报告了预先给予环磷酰胺后，全身照射后干细胞恢复情况得到增强。结果表明，与注入的骨髓干细胞再生相比，宿主自身存活的干细胞再生有更大程度的增强，这是由于启动再生的干细胞数量不同以及干细胞再生的时间进程所致。结果显示，尽管在所用剂量下该药物对干细胞相对有毒，但环磷酰胺产生的环境变化极大地增强了造血恢复。此外，已经表明，在3 - 8戈瑞（300 - 800拉德）范围内，干细胞再生水平几乎与γ射线剂量无关。如果人类骨髓有类似反应，那么就造血系统恢复而言，放疗前给予细胞毒性药物产生的再生体现了相当大的安全因素。
