两种用于检测恶性疾病患者血清中可溶性免疫复合物的125I C1q结合试验的比较。
A comparison of two 125I C1q binding tests to detect soluble immune complexes in serum of patients with malignant disease.
作者信息
Shepherd P S
出版信息
Clin Exp Immunol. 1979 May;36(2):250-5.
The 125I C1q deviation test and the modified 125I C1q PEG precipitation test were compared in their ability to detect soluble immune complexes in serum using a model system of HSA-rabbit-anti-HSA, and were then applied to sera collected from patients with malignant and non-malignant conditions. Despite close agreement in the model system, the two tests gave divergent results for the presence of C1q binding substances in individual serum samples collected from patients. The inherent complexities of interpreting C1q binding in serum, in terms of the presence of soluble immune complexes, makes it questionable whether either test can be relied upon to provide a means of identifying these complexes in the sera from patients with malignant disease.
使用人血清白蛋白-兔抗人血清白蛋白模型系统，比较了125I C1q偏差试验和改良的125I C1q聚乙二醇沉淀试验检测血清中可溶性免疫复合物的能力，然后将其应用于从患有恶性和非恶性疾病的患者收集的血清。尽管在模型系统中结果相近，但对于从患者收集的个体血清样本中C1q结合物质的存在情况，这两种试验给出了不同的结果。就可溶性免疫复合物的存在而言，解释血清中C1q结合的内在复杂性使得这两种试验能否可靠地用于识别恶性疾病患者血清中的这些复合物存在疑问。
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