Cashner F M, Schuyler M R, Salvaggio J E
Clin Exp Immunol. 1979 May;36(2):266-71.
Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibition, and positive 48-hr skin reactivity to M. faeni. Sensitized animals also demonstrated an augmented pulmonary histopathological response following respiratory challenge with M. faeni when compared to non-sensitized controls. Cortisone acetate abrogated this augmented pulmonary histopathological response following challenge with M. faeni. Cortisone acetate also abolished the positive alveolar macrophage migration inhibition found in sensitized animals.
通过气管内接种用费氏小多孢菌使兔子致敏，随后在激发前，对兔子注射或不注射醋酸可的松进行相同抗原激发。动物产生了抗费氏小多孢菌血清沉淀素、费氏小多孢菌诱导的肺泡巨噬细胞迁移抑制以及对费氏小多孢菌的48小时阳性皮肤反应。与未致敏的对照相比，致敏动物在用费氏小多孢菌进行呼吸道激发后，肺部组织病理学反应增强。醋酸可的松消除了用费氏小多孢菌激发后增强的肺部组织病理学反应。醋酸可的松还消除了在致敏动物中发现的阳性肺泡巨噬细胞迁移抑制。
