卡介苗诱导的兔肺迟发型超敏反应与加速肉芽肿形成的关系：醋酸可的松的作用
Relationship of BCG-induced pulmonary delayed hypersensitivity to accelerated granuloma formation in rabbit lungs: effect of cortisone acetate.
作者信息
Moore V L, Myrvik Q N
出版信息
Infect Immun. 1973 May;7(5):764-70. doi: 10.1128/iai.7.5.764-770.1973.
Abstract
The role of local pulmonary delayed hypersensitivity in accelerated pulmonary granuloma formation was investigated using cortisone acetate, an immunosuppressive drug that appears to preferentially eliminate committed lymphocytes at appropriate doses. Data are presented showing that cortisone acetate suppressed local pulmonary delayed hypersensitivity at the time of and subsequent to challenge with BCG. Furthermore, cortisone damage appeared to involve primarily committed lymphocyte populations since the defect was repairable with sensitized spleen cells, an unlikely source of macrophage precursors.
摘要
使用醋酸可的松（一种免疫抑制药物，在适当剂量下似乎优先消除已致敏淋巴细胞）研究了局部肺部迟发型超敏反应在加速肺部肉芽肿形成中的作用。所呈现的数据表明，醋酸可的松在卡介苗攻击时及攻击后抑制了局部肺部迟发型超敏反应。此外，醋酸可的松造成的损伤似乎主要涉及已致敏淋巴细胞群体，因为该缺陷可被致敏脾细胞修复，而脾细胞不太可能是巨噬细胞前体的来源。
相似文献
1
Relationship of BCG-induced pulmonary delayed hypersensitivity to accelerated granuloma formation in rabbit lungs: effect of cortisone acetate.卡介苗诱导的兔肺迟发型超敏反应与加速肉芽肿形成的关系：醋酸可的松的作用
Infect Immun. 1973 May;7(5):764-70. doi: 10.1128/iai.7.5.764-770.1973.
2
Specificity of a BCG-induced pulmonary granulomatous response in rabbits.卡介苗诱导的兔肺部肉芽肿反应的特异性
Infect Immun. 1973 May;7(5):743-6. doi: 10.1128/iai.7.5.743-746.1973.
3
Selective suppression of granuloma formation and delayed hypersensitivity in rabbits.兔肉芽肿形成和迟发型超敏反应的选择性抑制
Infect Immun. 1980 Apr;28(1):269-76. doi: 10.1128/iai.28.1.269-276.1980.
4
Cellular regulation of lung granuloma formation and delayed- type hypersensitivity induced with BCG cell walls. Further evidence of involvement of cellular immunity in lung granuloma formation.卡介苗细胞壁诱导的肺肉芽肿形成和迟发型超敏反应的细胞调节。细胞免疫参与肺肉芽肿形成的进一步证据。
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1982 Mar;251(3):357-68.
5
6
Immunosuppression by peritoneal BCG-induced granulomas in mice.小鼠腹膜内卡介苗诱导的肉芽肿所致免疫抑制
Braz J Med Biol Res. 1990;23(3-4):263-74.
7
Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.负责在兔肺中引发慢性免疫炎症反应的分枝杆菌成分。
Infect Immun. 1974 Jul;10(1):21-4. doi: 10.1128/iai.10.1.21-24.1974.
8
9
10
Effect of cortisone and cyclophosphamide on the immunological role of BCG in Balb/c mice challenged with Leishmania donovani.
Am J Trop Med Hyg. 1980 Jan;29(1):16-20. doi: 10.4269/ajtmh.1980.29.16.
引用本文的文献
1
Selective suppression of granuloma formation and delayed hypersensitivity in rabbits.兔肉芽肿形成和迟发型超敏反应的选择性抑制
Infect Immun. 1980 Apr;28(1):269-76. doi: 10.1128/iai.28.1.269-276.1980.
2
Glucocorticoid modulation of lymphokine-induced giant cell formation.糖皮质激素对淋巴因子诱导的巨细胞形成的调节作用。
Inflammation. 1984 Dec;8(4):393-406. doi: 10.1007/BF00918215.
3
Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.负责在兔肺中引发慢性免疫炎症反应的分枝杆菌成分。
Infect Immun. 1974 Jul;10(1):21-4. doi: 10.1128/iai.10.1.21-24.1974.
4
An animal model of hypersensitivity pneumonitis in the rabbit.兔超敏性肺炎动物模型
J Clin Invest. 1975 Oct;56(4):937-44. doi: 10.1172/JCI108173.
5
6
The antinflammatory effects of glucocorticosteroids. A brief review of the literature.糖皮质激素的抗炎作用。文献综述
Inflammation. 1979 Jul;3(3):329-43. doi: 10.1007/BF00914190.
本文引用的文献
1
Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits.抗巨噬细胞血清对兔皮肤结核菌素敏感性和过敏性肺肉芽肿形成的影响。
Infect Immun. 1970 Dec;2(6):810-4. doi: 10.1128/iai.2.6.810-814.1970.
2
Macrophage Migration Inhibition Studies with Cells from Mice Vaccinated with Cell Walls of Mycobacterium bovis BCG: Characterization of the Experimental System.用牛结核分枝杆菌细胞壁免疫的小鼠细胞进行巨噬细胞移动抑制研究：实验系统的特征。
Infect Immun. 1970 Jun;1(6):587-94. doi: 10.1128/iai.1.6.587-594.1970.
3
The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs.脱敏豚鼠中抗原反应性淋巴细胞的区室化
J Exp Med. 1971 Sep 1;134(3 Pt 1):741-50. doi: 10.1084/jem.134.3.741.
4
5
6
7
Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity.血吸虫卵周围形成肉芽肿是迟发型超敏反应的一种表现。
Am J Pathol. 1967 Nov;51(5):735-56.
8
Immunologic competence of thoracic duct cells. I. Delayed hypersensitivity.胸导管细胞的免疫能力。I. 迟发型超敏反应。
J Exp Med. 1966 Feb 1;123(2):267-81. doi: 10.1084/jem.123.2.267.
9
The inhibition of granuloma formation around Schistosoma mansoni eggs. 3. Heterologous antilymphocyte serum.曼氏血吸虫卵周围肉芽肿形成的抑制作用。3. 异种抗淋巴细胞血清。
Am J Pathol. 1968 Mar;52(3):613-31.
10
Changes in morphology and in lysozyme content of free alveolar cells after the intravenous injection of killed BCG in oil.静脉注射油剂灭活卡介苗后游离肺泡细胞形态及溶菌酶含量的变化
J Reticuloendothel Soc. 1968 Feb;5(1):33-53.
Zotero 插件