卡介苗诱导的兔肺迟发型超敏反应与加速肉芽肿形成的关系：醋酸可的松的作用
Relationship of BCG-induced pulmonary delayed hypersensitivity to accelerated granuloma formation in rabbit lungs: effect of cortisone acetate.
作者信息
Moore V L, Myrvik Q N
出版信息
Infect Immun. 1973 May;7(5):764-70. doi: 10.1128/iai.7.5.764-770.1973.
Abstract
The role of local pulmonary delayed hypersensitivity in accelerated pulmonary granuloma formation was investigated using cortisone acetate, an immunosuppressive drug that appears to preferentially eliminate committed lymphocytes at appropriate doses. Data are presented showing that cortisone acetate suppressed local pulmonary delayed hypersensitivity at the time of and subsequent to challenge with BCG. Furthermore, cortisone damage appeared to involve primarily committed lymphocyte populations since the defect was repairable with sensitized spleen cells, an unlikely source of macrophage precursors.
摘要
使用醋酸可的松（一种免疫抑制药物，在适当剂量下似乎优先消除已致敏淋巴细胞）研究了局部肺部迟发型超敏反应在加速肺部肉芽肿形成中的作用。所呈现的数据表明，醋酸可的松在卡介苗攻击时及攻击后抑制了局部肺部迟发型超敏反应。此外，醋酸可的松造成的损伤似乎主要涉及已致敏淋巴细胞群体，因为该缺陷可被致敏脾细胞修复，而脾细胞不太可能是巨噬细胞前体的来源。
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