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使用基于吸附剂的再生血液透析输送系统对甲醇和甲酸盐的清除不充分。

Inadequate removal of methanol and formate using the sorbent based regeneration hemodialysis delivery system.

作者信息

Whalen J E, Richards C J, Ambre J

出版信息

Clin Nephrol. 1979 Jun;11(6):318-21.

PMID:477050
Abstract

The sorbent based hemodialysis delivery system was shown to be ineffective for the treatment of methanol intoxication. Clinical and in vitro studies showed rapid saturation of the sorbent cartridge for methanol and formate adsorption. Methanol and formate clearances were four fold less than achieved with the recirculating single pass delivery system. The sorbent delivery system should not be used for methanol intoxication.

摘要

基于吸附剂的血液透析输送系统被证明对甲醇中毒治疗无效。临床和体外研究表明,吸附剂盒对甲醇和甲酸盐的吸附迅速饱和。甲醇和甲酸盐清除率比循环单通道输送系统低四倍。吸附剂输送系统不应被用于甲醇中毒治疗。

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Inadequate removal of methanol and formate using the sorbent based regeneration hemodialysis delivery system.使用基于吸附剂的再生血液透析输送系统对甲醇和甲酸盐的清除不充分。
Clin Nephrol. 1979 Jun;11(6):318-21.
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Serum formate concentrations in methanol intoxication as a criterion for hemodialysis.甲醇中毒时血清甲酸浓度作为血液透析的标准
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Toxicokinetics of formate during hemodialysis.血液透析期间甲酸盐的毒代动力学
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Methanol and formate kinetics during treatment with fomepizole.用甲吡唑治疗期间的甲醇和甲酸动力学
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Endogenous formate elimination and total body clearance during hemodialysis.血液透析期间内源性甲酸的清除及全身清除率
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Capillary electrophoresis with contactless conductometric detection for rapid screening of formate in blood serum after methanol intoxication.毛细管电泳-非接触电导检测法快速筛选甲醇中毒后血清中甲酸。
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Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning.在甲醇中毒治疗期间,间歇性血液透析在清除甲醇和甲酸方面优于连续性静脉-静脉血液透析/血液透析滤过。
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引用本文的文献

1
Acute methanol poisoning 'the blind drunk'.急性甲醇中毒——“失明性醉酒”
West J Med. 1981 Aug;135(2):122-8.
2
Methanol and ethylene glycol poisonings. Mechanism of toxicity, clinical course, diagnosis and treatment.甲醇和乙二醇中毒。毒性机制、临床病程、诊断与治疗。
Med Toxicol. 1986 Sep-Oct;1(5):309-34. doi: 10.1007/BF03259846.
3
Methanol poisoning.甲醇中毒。
Intensive Care Med. 1992;18(7):391-7. doi: 10.1007/BF01694340.