Urist M R, Lindholm T S, Mirra J M, Grant T T, Finerman G A
Clin Orthop Relat Res. 1979 Jun(141):275-80.
An osteoid osteoma, excised from the neck of the femur of a 23-year-old man, was cut into four 1.5 mm3 fragments and immediately transplanted into muscle pouches in athymic nude mice. One fragment was devitalized by lyophilization before implantation. The viable tumor cell xenografts grew, differentiated into uncalcified osteoid, and retained the characteristics of the original tumor. The killed implants were resorbed, but both the surviving viable and nonviable tumor tissue induced the connective tissue cells of the mouse host bed to proliferate and differentiate into normal cartilage and calcified bone. The mouse new bone deposits were remodeled and colonized by bone marrow, a tissue not seen in osteoid osteomas. These observations suggest that the sclerotic bone shell characteristic of osteoid osteomas may be an inductive reaction of host bed tissue to an osteoma cell product that is comparable to bone morphogenetic protein (BMP) produced by normal bone cells and transferred by normal bone matrix.
从一名23岁男性股骨颈切除的骨样骨瘤被切成四个1.5立方毫米的碎片，并立即移植到无胸腺裸鼠的肌肉袋中。其中一个碎片在植入前通过冻干使其失去活力。存活的肿瘤细胞异种移植物生长，分化为未钙化的骨样组织，并保留了原始肿瘤的特征。灭活的植入物被吸收，但存活的有活力和无活力的肿瘤组织都诱导小鼠宿主床的结缔组织细胞增殖并分化为正常软骨和钙化骨。小鼠的新骨沉积被重塑并被骨髓定植，而骨髓是骨样骨瘤中未见的组织。这些观察结果表明，骨样骨瘤特有的硬化骨壳可能是宿主床组织对骨瘤细胞产物的诱导反应，该产物类似于正常骨细胞产生并由正常骨基质传递的骨形态发生蛋白（BMP）。
