Bauer F C, Urist M R
Clin Orthop Relat Res. 1981 Sep(159):257-64.
Fresh biopsy specimens of three typical human giant cell tumors (GCT) were transplanted into athymic mice. The transplants were encapsulated in a host bed-derived fibrous connective tissue envelope. Multinucleated giant cells and mononucleated tumor cells survived chiefly on the vascularized surfaces of the inside of the envelope. Fibroblasts proliferated and filled the interior of the transplants where vascularization was relatively insufficient. Since mitotic figures were absent in multinucleated cells, the question arises whether only the mononuclear stroma cells are neoplastic in nature. Multinucleated cells occasionally showed endocytosed pyknotic cells, and survived transplantation for as long as 35 days. When the original tumor contained islands of osteoid and bone cells, the transplants induced differentiation of mouse host bed connective tissue into normal new bone, including bone marrow.
将三个典型的人类巨细胞瘤（GCT）新鲜活检标本移植到无胸腺小鼠体内。移植瘤被包裹在宿主床来源的纤维结缔组织包膜中。多核巨细胞和单核肿瘤细胞主要存活于包膜内部的血管化表面。成纤维细胞增殖并填充了移植瘤内部血管化相对不足的区域。由于多核细胞中未见有丝分裂象，因此产生了一个问题，即是否只有单核基质细胞本质上是肿瘤性的。多核细胞偶尔可见吞噬固缩核细胞，并在移植后存活长达35天。当原始肿瘤含有类骨质和骨细胞岛时，移植瘤可诱导小鼠宿主床结缔组织分化为正常的新骨，包括骨髓。
