氨和辛酸对大鼠肝脏再生的影响。
The influence of ammonia and octanoic acid on liver regeneration in the rat.
作者信息
Ellis W R, Chu P K, Murray-Lyon I M
出版信息
Clin Sci (Lond). 1979 Jan;56(1):95-7. doi: 10.1042/cs0560095.
PMID:477188
Abstract
- We have investigated the effect of intermittent doses of ammonia and octanoic acid on liver regeneration in the rat after partial hepatectomy. Regeneration was assessed by uptake of tritiated thymidine into liver deoxyribonucleic acid. 2. We have found a reduction in hepatic regenerative response in animals treated with ammonium acetate as a source of ammonia. 3. No inhibiting effect of octanoic acid on liver regeneration was found, at the dose used. 4. The implications of the results for management of fulminant hepatic failure are discussed.
摘要
- 我们研究了间歇性给予氨和辛酸对大鼠部分肝切除术后肝脏再生的影响。通过将氚标记的胸腺嘧啶核苷摄取到肝脏脱氧核糖核酸中来评估再生情况。2. 我们发现，以醋酸铵作为氨源处理的动物肝脏再生反应有所降低。3. 在所用剂量下，未发现辛酸对肝脏再生有抑制作用。4. 讨论了这些结果对暴发性肝衰竭治疗的意义。
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