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肝脏再生研究。体外和体内部分肝切除术后离体灌注肝脏中的脱氧核糖核酸合成。

Studies on liver regeneration. Deoxyribonucleic acid synthesis in the isolated perfused liver after in vitro and in vivo partial hepatectomy.

作者信息

Grandjean C, Garcia H

出版信息

Lab Invest. 1975 Apr;32(4):552-4.

PMID:1127874
Abstract

A new method for studying liver regeneration has been introduced. In the isolated perfused liver partial hepatectomy has been performed and -3H-thymidine incorporation into DNA was observed. The short term incorporation observed in vitro was comparable to that observed in vivo under similar conditions. The results suggest that similar regenerative mechanisms are operating in vivo and in vitro, and that the liver is at least one source of the regenerating stimuli.

摘要

一种研究肝脏再生的新方法已被引入。在离体灌注肝脏中进行了部分肝切除术,并观察到-3H-胸腺嘧啶核苷掺入DNA的情况。体外观察到的短期掺入情况与在类似条件下体内观察到的情况相当。结果表明,体内和体外存在相似的再生机制,并且肝脏至少是再生刺激的来源之一。

相似文献

1
Studies on liver regeneration. Deoxyribonucleic acid synthesis in the isolated perfused liver after in vitro and in vivo partial hepatectomy.肝脏再生研究。体外和体内部分肝切除术后离体灌注肝脏中的脱氧核糖核酸合成。
Lab Invest. 1975 Apr;32(4):552-4.
2
Treatment of cirrhotic rats with epidermal growth factor and insulin accelerates liver DNA synthesis after partial hepatectomy.用表皮生长因子和胰岛素治疗肝硬化大鼠可加速部分肝切除术后肝脏DNA的合成。
J Gastroenterol Hepatol. 1998 Dec;13(12):1259-65.
3
Bile acid-induced modifications in DNA synthesis by the regenerating perfused rat liver.胆汁酸对灌注的再生大鼠肝脏DNA合成的诱导性修饰。
Hepatology. 1993 Nov;18(5):1182-92.
4
[Replication of DNA associated with nuclear envelope of regenerating rat liver].[与再生大鼠肝细胞核膜相关的DNA复制]
Biokhimiia. 1977 Jun;42(6):1001-5.
5
Effects of biliary obstruction on hepatic deoxyribonucleic acid and protein synthesis after partial hepatectomy.胆管梗阻对部分肝切除术后肝脏脱氧核糖核酸及蛋白质合成的影响。
Hepatogastroenterology. 1997 Mar-Apr;44(14):501-7.
6
[Radioactivity of an acid-soluble liver fractions after administration of 3H-thymidine for the purpose of explaining the reasons for delayed DNA labeling].
Tsitologiia. 1978 Jun;20(6):670-5.
7
[Stimulating effect of histones on DNA synthesis in the regenerating rat liver].[组蛋白对再生大鼠肝脏中DNA合成的刺激作用]
Biokhimiia. 1976 Jul;41(6):1023-7.
8
Phenobarbital in comparison with carbon tetrachloride and phenobarbital-induced cirrhosis in rat liver regeneration.苯巴比妥与四氯化碳及苯巴比妥诱导的大鼠肝再生肝硬化的比较。
J Surg Res. 1999 Feb;81(2):164-9. doi: 10.1006/jsre.1998.5424.
9
[Reversible disorder of polyamine and DNA synthesis in regenerating rat liver].[再生大鼠肝脏中多胺与DNA合成的可逆性紊乱]
Biull Eksp Biol Med. 1980 Aug;90(8):165-7.
10
[Reutilization of tritiated thymidine and tritiated iododeoxyuridine for the synthesis of nuclear and mitochondrial DNA in regenerating rat liver].[氚标记胸腺嘧啶核苷和氚标记碘脱氧尿苷在再生大鼠肝脏中用于合成核DNA和线粒体DNA的再利用]
Arch Int Physiol Biochim. 1971 Oct;79(4):819-20.

引用本文的文献

1
Role of hepatocellular regeneration in chlordecone potentiated hepatotoxicity of carbon tetrachloride.肝细胞再生在开蓬增强四氯化碳肝毒性中的作用
Arch Toxicol. 1989;63(5):367-75. doi: 10.1007/BF00303125.
2
Morphology of nuclear ribonucleoproteins in the early period of liver regeneration.肝脏再生早期核糖核蛋白的形态学
Histochemistry. 1978 Aug 15;57(1):87-92. doi: 10.1007/BF00507358.