压力感受器反射在普萘洛尔对清醒自发性高血压大鼠心血管效应中的作用。

The role of the baroreceptor reflex in the cardiovascular effects of propranolol in the conscious spontaneously hypertensive rat.

Struyker-Boudier H A, Smits J F, Van Essen H

Clin Sci (Lond). 1979 Feb;56(2):163-7. doi: 10.1042/cs0560163.

Abstract

The role of baroreceptors in the cardiovascular mechanism of action of DL-propranolol has been studied by comparing the acute effects of subcutaneous injection of 1 and 5 mg/kg (3.3 x 10(-6) and 16.5 x 10(-6) mol/kg) of this drug in conscious baroreceptor-denervated spontaneously hypertensive (SH) rats with those in sham-operated control SH rats. 2. At 5 mg/kg (16.5 x 10(-6) mol/kg) propranolol caused a small, but significant, increase in blood pressure in sham-operated SH rats, whereas both after 1 and 5 mg/kg (3.3 x 10(-6) and 16.5 x 10(-6) mol/kg) immediate hypotension was observed in baroreceptor-denervated animals. 3. Heart rate dropped rapidly after injection of 1 or 5 mg/kg (3.3 x 10(-6) and 16.5 x 10(-6) mol/kg) propranolol both in the baroreceptor-denervated and sham-operated SH rats. Bradycardia was significantly larger in the baroreceptor-denervated animals after an injection of 5 mg/kg (16.5 x 10(-6) mol/kg). 4. It is concluded that the lack of an early hypotensive effect of propranolol in intact animals is caused by an increased baroreceptor reflex activity as a consequence of the fall in cardiac output.

摘要

通过比较皮下注射1和5mg/kg（3.3×10⁻⁶和16.5×10⁻⁶mol/kg）剂量的DL-普萘洛尔对清醒的去压力感受器自发性高血压（SH）大鼠和假手术对照SH大鼠的急性效应，研究了压力感受器在DL-普萘洛尔心血管作用机制中的作用。2. 在假手术的SH大鼠中，5mg/kg（16.5×10⁻⁶mol/kg）的普萘洛尔使血压有小幅但显著的升高，而在去压力感受器的动物中，注射1和5mg/kg（3.3×10⁻⁶和16.5×10⁻⁶mol/kg）后均立即出现低血压。3. 在去压力感受器和假手术的SH大鼠中，注射1或5mg/kg（3.3×10⁻⁶和16.5×10⁻⁶mol/kg）普萘洛尔后心率均迅速下降。注射5mg/kg（16.5×10⁻⁶mol/kg）后，去压力感受器动物的心动过缓明显更严重。4. 得出结论，在完整动物中普萘洛尔缺乏早期降压作用是由于心输出量下降导致压力感受器反射活动增强所致。