Carrow D J, Aldrete J A, Masden R R, Jackson D
Anesth Analg. 1975 Mar-Apr;54(2):262-6. doi: 10.1213/00000539-197503000-00027.
A bolus of 3 mg. of atropine was given intravenously (I.V.) TO 123 ANESTHETIZED PATIENTS. Increases in heart rate were seen in 109 patients (88 percent), while 7 patients (5.7 percent) had no change. A mean increase in systolic arterial blood pressure of 14 mm. Hg was noted. A certain pattern in increases in heart rate and systolic blood pressure was observed. Ninety-six percent of the patients under cyclopropane, fluroxene, ether, ketamine, or regional (spinal or epidural) anesthesia had heart-rate increases, compared with only 77 to 89 percent of the patients anesthetized with halothane, enflurane, or neuroleptanalgesics. Rise in systolic blood pressure was seen in 40 to 50 percent of the former, but only in 31 to 40 percent of the latter group. The arrhythmias observed were transient A-V junctional tachycardias in three instances and bigeminal rhythm in one patient under cyclopropane anesthesia, The administration of a vagolytic dose of atropine to anesthetized patients appears not to be as arrhythmogenic as previously considered.
对123例麻醉患者静脉注射（I.V.）3毫克阿托品。109例患者（88%）心率增加，7例患者（5.7%）心率无变化。收缩动脉血压平均升高14毫米汞柱。观察到心率和收缩压升高存在一定模式。接受环丙烷、氟烷、乙醚、氯胺酮或区域（脊髓或硬膜外）麻醉的患者中，96%心率增加，而接受氟烷、恩氟烷或神经安定镇痛麻醉的患者中，这一比例仅为77%至89%。前者40%至50%的患者收缩压升高，而后者组仅为31%至40%。观察到的心律失常为3例短暂性房室交界性心动过速和1例环丙烷麻醉患者的二联律。对麻醉患者给予抗迷走神经剂量的阿托品似乎不像以前认为的那样容易引发心律失常。
