棕榈酰辅酶A合成酶。一种酶结合中间体的分离。
Palmitoyl-coenzyme A synthetase. Isolation of an enzyme-bound intermediate.
作者信息
Bar-Tana J, Rose G, Shapiro B
出版信息
Biochem J. 1973 Nov;135(3):411-6. doi: 10.1042/bj1350411.
Abstract
An enzyme-bound intermediate of the overall reaction catalysed by rat liver microsomal long-chain fatty acyl-CoA synthetase is described. It was found to contain equimolar amounts of adenylate and fatty acid moieties bound to protein, and was stabilized by ATP. The intermediate reacted with CoA to give palmitoyl-CoA.
摘要
本文描述了大鼠肝脏微粒体长链脂肪酰辅酶A合成酶催化的整体反应的一种酶结合中间体。发现它含有与蛋白质结合的等摩尔量的腺苷酸和脂肪酸部分，并由ATP稳定。该中间体与辅酶A反应生成棕榈酰辅酶A。
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本文引用的文献
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The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection.双底物或多底物及多产物酶催化反应的动力学。III. 通过观察预测初速度和抑制模式
Biochim Biophys Acta. 1963 Feb 12;67:188-96. doi: 10.1016/0006-3002(63)91816-x.
2
Acyl adenylates; an enzymatic mechanism of acetate activation.酰基腺苷酸；乙酸激活的一种酶促机制。
J Biol Chem. 1956 Oct;222(2):991-1013.
3
A relation between non-esterified fatty acids in plasma and the metabolism of glucose.血浆中非酯化脂肪酸与葡萄糖代谢之间的关系。
J Clin Invest. 1956 Feb;35(2):150-4. doi: 10.1172/JCI103259.
4
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Biochem J. 1971 Apr;122(3):353-62. doi: 10.1042/bj1220353.
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Some questions about the structure and activity of aminoacyl-tRNA synthetases.关于氨酰-tRNA合成酶的结构与活性的一些问题。
Adv Enzymol Relat Areas Mol Biol. 1971;35:443-501. doi: 10.1002/9780470122808.ch8.
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Substrate synergism and phosphoenzyme formation in catalysis by succinyl coenzyme A synthetase.琥珀酰辅酶A合成酶催化中的底物协同作用与磷酸酶形成
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8
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9
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