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卤代羟基喹啉对犬的毒性。一项临床研究。I. 病例调查。

Toxicity of halogenated oxyquinolines in dogs. A clinical study. I. A survey of cases.

作者信息

Lannek B

出版信息

Acta Vet Scand. 1973 May;14(5):723-44. doi: 10.1186/BF03547401.

DOI:10.1186/BF03547401
PMID:4772605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8559802/
Abstract

A survey of 100 cases of oxyquinoline poisoning in dogs is presented. The disease, characterized by hyperexcitability of the CNS with convulsions as well as heart and liver injury, runs an acute course. The mortality (euthanized dogs included) was 30 Case-history data showed that the oxyquinoline treatment which preceded the disease was given because the dog had incidental diarrhoea. In most cases the drugs were administered for only 1 day before the dog fell ill. The median time from the last dose to onset of symptoms was 12 hrs. Old dogs were affected more often than expected and also showed higher mortality than did young dogs.

摘要

本文呈现了对100例犬氧喹啉中毒病例的调查。该病以中枢神经系统兴奋、惊厥以及心脏和肝脏损伤为特征,病程呈急性。死亡率(包括安乐死的犬)为30%。病例史数据显示,在发病前进行氧喹啉治疗是因为犬出现了偶发性腹泻。在大多数情况下,药物仅在犬发病前1天给药。从最后一剂药物到症状出现的中位时间为12小时。老年犬比预期更常受到影响,且死亡率也高于幼犬。

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Toxicity of halogenated oxyquinolines in dogs. A clinical study. I. A survey of cases.卤代羟基喹啉对犬的毒性。一项临床研究。I. 病例调查。
Acta Vet Scand. 1973 May;14(5):723-44. doi: 10.1186/BF03547401.
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引用本文的文献

1
Toxicity of halogenated oxyquinolines in dogs. A clinical study. V. Pathological findings.犬类中卤代羟基喹啉的毒性。一项临床研究。V. 病理结果。
Acta Vet Scand. 1974;15(4):461-86. doi: 10.1186/BF03547220.
2
Toxicity of halogenated oxyquinolines in dogs. A clinical study. 3. Intoxication experiments.卤代羟基喹啉对犬的毒性。一项临床研究。3. 中毒实验。
Acta Vet Scand. 1974;15(3):398-418. doi: 10.1186/BF03547467.
3
Toxicity of halogenated oxyquinolines in dogs. A clinical study. IV. Tissue distribution and elimination in urine.犬类中卤代羟基喹啉的毒性。一项临床研究。IV. 组织分布及尿液排泄
Acta Vet Scand. 1974;15(3):419-35. doi: 10.1186/BF03547468.

本文引用的文献

1
Comparative studies on the iodine absorption of anayodin, chiniofon, diodoquin, and vioform in man.人对安那碘、喹碘方、双碘喹啉和碘仿碘吸收的比较研究。
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[STUDIES ON PRIMARY ALTERATIONS ON THE DISTAL KIDNEY TUBULE IN RATS WITH DISORDER OF THE HAIRPIN COUNTER-CURRENT SYSTEM].[对髓袢逆流系统紊乱大鼠远端肾小管原发性改变的研究]
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[EXPERIMENTAL INDUCTION OF CHANGES IN THE DISTAL RENAL TUBULE BY HALOGENATED QUINOLINE AND QUINALDINE DERIVATIVES].[卤代喹啉和喹哪啶衍生物对远端肾小管变化的实验诱导]
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PROPHYLAXIS AND THERAPY OF AMEBIASIS AND SHIGELLOSIS WITH IODOCHLORHYDROXYQUIN.用氯碘羟喹对阿米巴病和志贺氏菌病进行预防和治疗
Am J Trop Med Hyg. 1964 May;13:396-401. doi: 10.4269/ajtmh.1964.13.396.
5
Kidney damage in hamsters receiving an artificial diet containing 5,7-dichloro-8-hydroxychinaldine.食用含5,7-二氯-8-羟基喹哪啶的人工饲料的仓鼠的肾脏损伤
Acta Pharmacol Toxicol (Copenh). 1961;18:249-54. doi: 10.1111/j.1600-0773.1961.tb01664.x.
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Urinary excretions of vioform and diodoquin in rabbits.兔体内碘仿和双碘喹啉的尿排泄情况。
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[Comparative studies on the resorption and metabolism of a therapeutically-used 8-hydroxyquinoline].[一种治疗用8-羟基喹啉的吸收与代谢的比较研究]
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[Acute cerebral disorders following high doses of an oxyquinoline derivative].[高剂量氧喹啉衍生物后的急性脑部疾病]
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[Possible neurotoxicity of oxyquinolines].
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