对外淋巴生理学的贡献。第四部分：组胺对耳蜗微循环的影响。

A contribution to the physiology of the perilymph. Part IV: Effect of histamine on the cochlear microcirculation.

作者信息

Schnieder E A

出版信息

Ann Otol Rhinol Laryngol. 1975 Mar-Apr;84(2 PART 1):228-32. doi: 10.1177/000348947508400216.

Abstract

Summary--Because of the topography of the perilymphatic vascular network, the cochlear microcirculation is especially sensitive to the effect of vasoactive substances reaching the perilymphatic space. The cochlear microcirculation is mainly controlled humorally, via the activity of the metarterioles and changes in the flow properties of the blood. Intracochlear histamine reduces the cochlear circulation even more markedly than after intracarotid administration. No systematic effects of parenteral administration of vasoactive substances can be expected on the cochlear circulation. Reversible auditory disorders after stapedectomy may be explicable by the intracochlear release of histamine. The internal release of histamine after sunstroke and cold stress may play a part in sudden dusturbances of hearing.

摘要

总结——由于外淋巴血管网络的形态结构，耳蜗微循环对进入外淋巴间隙的血管活性物质的作用尤为敏感。耳蜗微循环主要通过微动脉的活动和血液流动特性的变化进行体液调节。耳蜗内注射组胺比颈内动脉注射后更显著地降低耳蜗循环。预计胃肠外给予血管活性物质对耳蜗循环不会产生系统性影响。镫骨切除术后可逆性听觉障碍可能是由于耳蜗内组胺释放所致。中暑和冷应激后组胺的内源性释放可能在突发性听力障碍中起作用。