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血-外淋巴屏障

The blood-perilymph barrier.

作者信息

Jahnke K

出版信息

Arch Otorhinolaryngol. 1980;228(1):29-34. doi: 10.1007/BF00455891.

DOI:10.1007/BF00455891
PMID:7469927
Abstract

Freeze fracture replicas of the guinea pig inner ear were studied under the electron microscope to define the blood-perilymph barrier morphologically. This barrier is represented basically by the continuous endothelium of the inner ear capillaries. The endothelial cells contain only a few micropinocytotic vesicles in contrast to those of the stria vascularis vessels. The cochlear plexus also exhibits some special differences. Tight junctions of the continuous mesothelial type connect the endothelial cells of the inner ear capillaries. Cell membranes of these cells possess a lower particle density than those of the stria vascularis vessels. In general, the blood-perilymph barrier is morphologically similar to the blood-brain barrier.

摘要

在电子显微镜下研究豚鼠内耳的冷冻断裂复制品,以便从形态学上界定血-外淋巴屏障。该屏障基本上由内耳毛细血管的连续内皮构成。与血管纹血管的内皮细胞相比,内皮细胞仅含有少量微饮小泡。耳蜗丛也表现出一些特殊差异。连续间皮类型的紧密连接连接内耳毛细血管的内皮细胞。这些细胞的细胞膜比血管纹血管的细胞膜具有更低的颗粒密度。一般来说,血-外淋巴屏障在形态上与血脑屏障相似。

相似文献

1
The blood-perilymph barrier.血-外淋巴屏障
Arch Otorhinolaryngol. 1980;228(1):29-34. doi: 10.1007/BF00455891.
2
[Permeability barriers of the inner ear. Fine structure and function].[内耳的渗透屏障。精细结构与功能]
Fortschr Med. 1980 Mar 6;98(9):330-6.
3
Fine structure and permeability of capillaries in the stria vascularis and spiral ligament of the inner ear of the guinea pig.豚鼠内耳血管纹和螺旋韧带中毛细血管的精细结构与通透性
Cell Tissue Res. 1982;226(3):511-22. doi: 10.1007/BF00214780.
4
A survey of the effects of loop diuretics on the zonulae occludentes of the perilymph-endolymph barrier by freeze fracture.通过冷冻断裂技术对袢利尿剂对内淋巴-外淋巴屏障紧密连接影响的研究。
Acta Otolaryngol. 1982 Sep-Oct;94(3-4):307-16. doi: 10.3109/00016488209128918.
5
The fine structure of the cochlear plexus.耳蜗丛的精细结构。
Arch Otorhinolaryngol. 1980;228(3):155-61. doi: 10.1007/BF00454223.
6
Inner ear pressure measurements. Effects of obstruction of the cochlear aqueduct and endolymphatic duct on the perilymphatic pressure.内耳压力测量。蜗水管和内淋巴管阻塞对外淋巴压力的影响。
Otolaryngol Clin North Am. 1983 Feb;16(1):21-35.
7
Perilymphatic communication routes in the auditory and vestibular system.听觉和前庭系统中的外淋巴沟通途径。
Otolaryngol Head Neck Surg. 1981 Sep-Oct;89(5):822-30. doi: 10.1177/019459988108900525.
8
[Blockage of cochlear aqueduct for examination of perilymph (guinea pig) (author's transl)].[豚鼠耳蜗导水管阻塞用于外淋巴检查(作者译)]
Arch Otorhinolaryngol. 1979;224(3-4):257-65.
9
Ionic environment of cochlear hair cells.耳蜗毛细胞的离子环境。
Hear Res. 1986;22:279-93. doi: 10.1016/0378-5955(86)90104-8.
10
Early alterations of cochlear function in experimental perilymph fistulas.实验性外淋巴瘘中耳蜗功能的早期改变
Laryngoscope. 1990 Apr;100(4):389-94. doi: 10.1288/00005537-199004000-00011.

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Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects.噪声性感音神经性听力损失与高血压之间的相互作用:病理生理机制与治疗前景。
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本文引用的文献

1
Passage of dextran molecules across the blood-lymph barrier.葡聚糖分子穿过血-淋巴屏障。
Acta Chir Scand Suppl. 1956;211:1-84.
2
Passage of molecules through capillary wals.分子通过毛细血管壁的过程。
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The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.以过氧化物酶为示踪剂研究毛细血管通透性的超微结构基础。
4小时延迟钆增强磁共振成像上的灰度表现提示突发性感音神经性听力损失中的严重内耳病变及症状。
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Exploring Inner Ear and Brain Connectivity through Perilymph Sampling for Early Detection of Neurological Diseases: A Provocative Proposal.通过外淋巴采样探索内耳与脑的连通性以早期检测神经疾病:一项具有启发性的提议。
Brain Sci. 2024 Jun 20;14(6):621. doi: 10.3390/brainsci14060621.
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Hearing loss and its association with the proteome of perilymph, cerebrospinal fluid, and tumor tissue in patients with vestibular schwannoma.前庭神经鞘瘤患者的听力损失及其与外淋巴液、脑脊液和肿瘤组织蛋白质组的关系。
Sci Rep. 2024 Jun 19;14(1):14118. doi: 10.1038/s41598-024-64352-6.
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Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.阿尔茨海默病小鼠模型中海马周细胞蛋白景观的紊乱。
PLoS One. 2024 May 10;19(5):e0303375. doi: 10.1371/journal.pone.0303375. eCollection 2024.
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The Clinical Effect of Steroids for Hearing Preservation in Cochlear Implantation: Conclusions Based on Three Cochlear Implant Systems and Two Administration Regimes.类固醇在人工耳蜗植入中听力保留的临床效果:基于三种人工耳蜗系统和两种给药方案的结论
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Inner Ear Drug Delivery for Sensorineural Hearing Loss: Current Challenges and Opportunities.用于感音神经性听力损失的内耳药物递送:当前挑战与机遇
Front Neurosci. 2022 May 24;16:867453. doi: 10.3389/fnins.2022.867453. eCollection 2022.
9
LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB).低密度脂蛋白受体相关蛋白 1(LRP1),血迷路屏障(BLB)开放的新靶点。
Signal Transduct Target Ther. 2022 Jun 10;7(1):175. doi: 10.1038/s41392-022-00995-z.
10
The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea.速尿对豚鼠耳蜗中钠-钾-氯协同转运蛋白-1、胎球蛋白-A和色素上皮衍生因子的急性影响
Front Mol Neurosci. 2022 Mar 22;15:842132. doi: 10.3389/fnmol.2022.842132. eCollection 2022.
J Cell Biol. 1967 Oct;35(1):213-36. doi: 10.1083/jcb.35.1.213.
4
Horseradish peroxidase in the lateral cochlear wall. An electron microscopic study of transport.耳蜗外侧壁中的辣根过氧化物酶。运输的电子显微镜研究。
Arch Otolaryngol. 1971 Mar;93(3):304-16. doi: 10.1001/archotol.1971.00770060442015.
5
Freeze-fracture appearance of the capillary endothelium in the cerebral cortex of mouse brain.小鼠大脑皮质毛细血管内皮细胞的冷冻断裂外观。
Am J Anat. 1974 Aug;140(4):595-9. doi: 10.1002/aja.1001400412.
6
The permeability of blood vessels in the guinea pig cochlea. II. Vessels in the spiral ligament and the stria vascularis.豚鼠耳蜗血管的通透性。II. 螺旋韧带和血管纹中的血管。
Anat Embryol (Berl). 1974;146(1):33-42. doi: 10.1007/BF00341381.
7
The permeability of blood vessels in the guinea pig cochlea. I. Vessels of the modiolus and spiral vessel.
Anat Embryol (Berl). 1974;146(1):21-31. doi: 10.1007/BF00341380.
8
Diffusion barrier to horseradish peroxidase in the vascular stria of the guinea pig.
Z Zellforsch Mikrosk Anat. 1971;121(4):499-506. doi: 10.1007/BF00560156.
9
Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia.“紧密”和“渗漏”上皮细胞的紧密连接带的断裂面。
J Cell Biol. 1973 Aug;58(2):390-400. doi: 10.1083/jcb.58.2.390.
10
Ultrastructure of toe cochlear blood vessels.耳蜗血管的超微结构。 (注:原文中“toe”应该是“cochlear”的拼写错误,这里按照正确的“cochlear”进行翻译)
Acta Otolaryngol. 1974 Apr;77(4):231-50.