Brook I
Chest. 1979 Oct;76(4):420-4. doi: 10.1378/chest.76.4.420.
Serial tracheal cultures for aerobic and anaerobic bacteria were obtained from 27 pediatric patients during one year of follow-up. The patients had required tracheostomy and prolonged intubation for periods ranging from 3 to 12 months (average, 7 1/2 months). Cultures of tracheal aspirates yielded 1,508 isolates of pathogenic aerobic (969 isolates) and anaerobic (539 isolates) bacteria. The most frequent aerobic isolates were Streptococcus pneumoniae and Staphylococcus aureus. The predominant anaerobes were anaerobic gram-positive cocci, Fusobacterium nucleatum, and Bacteroides fragilis. Replacement of one pathogen by another occurred frequently. Tracheobronchitis occurred in 24 patients, all of whom had episodes of pneumonia. The data suggest that anaerobic bacteria are a part of the bacterial flora in colonization, tracheobronchitis, and pneumonia in patients with tracheostomy and prolonged intubation.
在为期一年的随访期间，从27名儿科患者中获取了用于需氧菌和厌氧菌培养的系列气管样本。这些患者均接受了气管造口术，并进行了3至12个月（平均7个半月）的长期插管。气管吸出物培养共得到1508株致病性需氧菌（969株）和厌氧菌（539株）。最常见的需氧菌分离株是肺炎链球菌和金黄色葡萄球菌。主要的厌氧菌是厌氧革兰氏阳性球菌、具核梭杆菌和脆弱拟杆菌。一种病原体被另一种病原体取代的情况频繁发生。24名患者发生了气管支气管炎，所有患者均有肺炎发作。数据表明，厌氧菌是气管造口术和长期插管患者定植、气管支气管炎及肺炎细菌菌群的一部分。
