金抗原携带者的家族聚集性。
Familial accumulation of carriers of Au antigen.
作者信息
Helske T, Nevanlinna H R
出版信息
J Med Genet. 1973 Sep;10(3):270-2. doi: 10.1136/jmg.10.3.270.
The sibs and parents of 83 Au-positive blood donors were tested in order to study the possible family clustering of Au positives in a population with a low frequency of carriers of Australia (Au) antigen. Tested by counterelectrophoresis the incidence of Au antigen in the parents of Au-positive persons is 5·4% and in the sibs 17·9%, compared to 0·15% in blood donors. The hypothesis that the Au-carrier state is genetically determined was tested by calculating the proportion of Au-positive children in the families. The results are not inconsistent with a recessive mode of inheritance but do not allow definitive conclusions to be drawn.
对83名抗澳（Au）阳性献血者的亲属及父母进行检测，以便在澳大利亚（Au）抗原携带者频率较低的人群中研究抗澳阳性者可能存在的家族聚集性。通过对流电泳检测发现，抗澳阳性者父母中澳抗原的发生率为5.4%，其同胞中为17.9%，而献血者中的发生率为0.15%。通过计算家庭中抗澳阳性儿童的比例，对澳抗原携带者状态由基因决定这一假说进行了检验。结果与隐性遗传模式并不矛盾，但无法得出确定性结论。
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