Krejcí I, Kupková B, Metys J, Barth T, Jost K
Eur J Pharmacol. 1979 Jul 1;56(4):347-53. doi: 10.1016/0014-2999(79)90265-6.
The effects of several types of vasopressin analogs that are considered to be resistant to some of the physiologically significant enzymatic systems were investigated utilizing rats trained in a passive avoidance task. Enhancement of avoidance latencies was observed 2, 7 and 13 days after the single learning trial when deamino-carbavasopressins, triglycyl-8-lysine-vasopressin or its des-glycinamide derivative, and deamino-D-arginine-vasopressin were given shortly after the learning trial in the dose of 1 microgram s.c. (8-L-Arginine)deamino-6-carba-vasopressin and (8-L-ornithine)deamino-6-carba-vasopressin were also active in the dose of 0.1 microgram. Lysine vasopressin and its des-glycinamide derivative failed to enhance avoidance latencies in part of the experiments if doses of 0.3--3 micrograms were administered and 7 or 13 day intervals were used between the learning and the test trials. Enhancement of avoidance latencies was also observed, if some of the peptides were injected 20 min but not 120 or 180 min before the test trial. Marked depression of exploratory behavior of rats in an open field was found after s.c. injections of low doses (1--3 micrograms kg-1) of deamino-carba-vasopressins. Higher doses (10--30 micrograms kg-1) induced sleep-like immobility not accompanied by ataxia or catalepsy.
利用在被动回避任务中训练过的大鼠，研究了几种被认为对某些具有生理意义的酶系统有抗性的血管加压素类似物的作用。在单次学习试验后2天、7天和13天，当在学习试验后不久皮下注射1微克剂量的去氨基-卡巴血管加压素、三甘氨酰-8-赖氨酸-血管加压素或其去甘氨酰胺衍生物以及去氨基-D-精氨酸血管加压素时，观察到回避潜伏期延长。（8-L-精氨酸）去氨基-6-卡巴血管加压素和（8-L-鸟氨酸）去氨基-6-卡巴血管加压素在0.1微克剂量时也有活性。在部分实验中，如果给予0.3 - 3微克剂量的赖氨酸血管加压素及其去甘氨酰胺衍生物，并且在学习试验和测试试验之间间隔7天或13天，则未能延长回避潜伏期。如果在测试试验前20分钟而不是120分钟或180分钟注射某些肽，也观察到回避潜伏期延长。皮下注射低剂量（1 - 3微克/千克）的去氨基-卡巴血管加压素后，发现大鼠在旷场中的探索行为明显受到抑制。较高剂量（10 - 30微克/千克）会诱导类似睡眠的不动状态，且不伴有共济失调或僵住症。
