Krejcí I, Kupková B, Dlabac A
Regul Pept. 1981 Sep;2(5):285-91. doi: 10.1016/0167-0115(81)90033-1.
Deamino-6-carba-oxytoxin (dC60), a potent oxytocin analog considered to be resistant to some of the physiologically significant enzymic systems, and N-alpha-acetyl-[2-O-methyltyrosine]oxytocin (AMTO), an analog acting as a competitive inhibitor of oxytocin on the rat uterus, were studied in rats trained in a passive avoidance task. Subcutaneous administration of dC60 (5-50 microgram . kg-1) during different phases of the passive avoidance learning paradigm attenuated avoidance latencies; the results indicated that the drug induced state-dependent learning. AMTO (5-20 microgram . kg-1) enhanced avoidance latencies when administered subcutaneously before training trials and/or before retention test trials. This effect occurred in both males and females. The analogs did not influence exploratory behavior in open field. The results suggest that oxytoxin, in contrast to vasopressin, may impair memory processes. However, both analogs failed to influence the passive avoidance response when administered after training. This finding indicates that dC60 and AMTO did not influence the mechanism of memory consolidation whereas vasopressin and oxytoxin had a marked effect.
脱氨基-6-碳-氧毒素（dC60）是一种强效的催产素类似物，被认为对某些具有生理意义的酶系统具有抗性；N-α-乙酰基-[2-O-甲基酪氨酸]催产素（AMTO）是一种在大鼠子宫上作为催产素竞争性抑制剂起作用的类似物。我们在接受被动回避任务训练的大鼠中对它们进行了研究。在被动回避学习范式的不同阶段皮下注射dC60（5 - 50微克·千克-1）会缩短回避潜伏期；结果表明该药物诱导了状态依赖性学习。在训练试验前和/或保留测试试验前皮下注射AMTO（5 - 20微克·千克-1）会延长回避潜伏期。这种效应在雄性和雌性大鼠中均有出现。这些类似物不影响旷场中的探索行为。结果表明，与加压素相比，催产素可能会损害记忆过程。然而，在训练后给药时，这两种类似物均未影响被动回避反应。这一发现表明，dC60和AMTO不影响记忆巩固机制，而加压素和催产素则有显著影响。
