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Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II.

作者信息

Cordopatis P, Brison J, Dirkx J, Theodoropoulos D

出版信息

Experientia. 1979 Jul 15;35(7):849-50. doi: 10.1007/BF01955103.

DOI:10.1007/BF01955103
PMID:477828
Abstract

[1-N4-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertension (Ciba). Rabbit aorta strips gave intrinsic activity alpha E = 1, a PD2 of 6.92 +/- 0.09 and an affinity relative to [Asn1]-angiotensin II of 6.5%.

摘要

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引用本文的文献

1
Synthesis of [1-Aib]-angiotensin II, an analogue with higher potency than [1-Asn,5-Val]-angiotensin II.[1-氨基异丁酸]-血管紧张素II的合成，一种比[1-天冬酰胺,5-缬氨酸]-血管紧张素II效力更高的类似物。
Experientia. 1983 Jan 15;39(1):106-8. doi: 10.1007/BF01960656.

本文引用的文献

1
Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride.无水氟化氢在肽合成中的应用。I. 各种保护基在无水氟化氢中的行为。
Bull Chem Soc Jpn. 1967 Sep;40(9):2164-7. doi: 10.1246/bcsj.40.2164.
2
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.用于检测肽固相合成中游离末端氨基的颜色测试。
Anal Biochem. 1970 Apr;34(2):595-8. doi: 10.1016/0003-2697(70)90146-6.
3
Pressor action of beta blocking agents in rats.β受体阻滞剂对大鼠的升压作用。
Can J Physiol Pharmacol. 1970 Jul;48(7):481-9. doi: 10.1139/y70-074.
4
Improvement to the esterification procedure used in solid phase peptide synthesis.
Int J Protein Res. 1971;3(5):297-9. doi: 10.1111/j.1399-3011.1971.tb01723.x.
5
Synthesis of analogs of (8-isoleucine)angiotensin II with variations in position 1.1位有变化的（8-异亮氨酸）血管紧张素II类似物的合成
J Med Chem. 1974 Apr;17(4):431-3. doi: 10.1021/jm00250a013.
6
Angiotensin analogs: the influence of sarcosine substituted in position 1.血管紧张素类似物：1位肌氨酸取代的影响。
J Pharmacol Exp Ther. 1974 Jan;188(1):222-8.
7
Factors that influence the antagonistic properties of angiotensin II antagonists.
J Med Chem. 1973 Jul;16(7):829-32. doi: 10.1021/jm00265a018.
8
Myotropic actions of angiotensin and noradrenaline in strips of rabbit aortae.血管紧张素和去甲肾上腺素对兔主动脉条的肌性作用。
Can J Physiol Pharmacol. 1977 Oct;55(5):1056-69. doi: 10.1139/y77-145.