Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II.
作者信息
Cordopatis P, Brison J, Dirkx J, Theodoropoulos D
出版信息
Experientia. 1979 Jul 15;35(7):849-50. doi: 10.1007/BF01955103.
PMID:477828
Abstract
[1-N4-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertension (Ciba). Rabbit aorta strips gave intrinsic activity alpha E = 1, a PD2 of 6.92 +/- 0.09 and an affinity relative to [Asn1]-angiotensin II of 6.5%.
摘要
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