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S-腺苷-L-高半胱氨酸的各种类似物对人红细胞中蛋白甲基转移酶II的结合能力。

Binding capacities of various analogues of S-adenosyl-L-homocysteine to protein methyltransferase II from human erythrocytes.

作者信息

Gillet L, Looze Y, Deconinck M, Léonis J

出版信息

Experientia. 1979 Aug 15;35(8):1007-9. doi: 10.1007/BF01949909.

DOI:10.1007/BF01949909
PMID:477857
Abstract

A series of analogues of S-adenosyl-L-homocysteine, modified mainly in the amino acid portion of the molecule, have been synthesized. All were found to be competitive inhibitors of protein methyltransferase II from human erythrocytes. S-adenosyl-L-homocysteine remains however by far the most effective inhibitor of the methylase.

摘要

已经合成了一系列主要在分子的氨基酸部分进行修饰的S-腺苷-L-高半胱氨酸类似物。发现所有这些类似物都是人红细胞中蛋白质甲基转移酶II的竞争性抑制剂。然而，S-腺苷-L-高半胱氨酸仍然是迄今为止甲基化酶最有效的抑制剂。

相似文献

1
Binding capacities of various analogues of S-adenosyl-L-homocysteine to protein methyltransferase II from human erythrocytes.S-腺苷-L-高半胱氨酸的各种类似物对人红细胞中蛋白甲基转移酶II的结合能力。
Experientia. 1979 Aug 15;35(8):1007-9. doi: 10.1007/BF01949909.
2
Inhibition of protein methyltransferases II from human erythrocytes by S-adenosyl-L-homocysteine and structurally related molecules [proceedings].
Arch Int Physiol Biochim. 1979 Aug;87(3):632-3.
3
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 7. Role of the ribosyl moiety in enzymatic binding of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。7. 核糖基部分在S-腺苷-L-高半胱氨酸和S-腺苷-L-甲硫氨酸酶促结合中的作用。
J Med Chem. 1978 Dec;21(12):1307-10. doi: 10.1021/jm00210a026.
4
Protein methylation in animal cells. II. Inhibition of S-adenosyl-L-methionine:protein(arginine) N-methyltransferase by analogs of S-adenosyl-L-homocysteine.动物细胞中的蛋白质甲基化。II. S-腺苷-L-高半胱氨酸类似物对S-腺苷-L-甲硫氨酸：蛋白质（精氨酸）N-甲基转移酶的抑制作用。
Biochim Biophys Acta. 1978 Jun 22;519(1):255-68. doi: 10.1016/0005-2787(78)90078-3.
5
Purification of protein methylase II from human erythrocytes.从人红细胞中纯化蛋白质甲基化酶II
J Biochem Biophys Methods. 1983 Aug;8(1):9-14. doi: 10.1016/0165-022x(83)90016-7.
6
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 4. Further modifications of the amino and base portions of S-adenosyl-L-homocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。4. S-腺苷-L-高半胱氨酸氨基和碱基部分的进一步修饰。
J Med Chem. 1976 Sep;19(9):1094-9. doi: 10.1021/jm00231a003.
7
Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.S-腺苷-L-同型半胱氨酸对完整红细胞中蛋白质羧基甲基化的抑制作用。生理后果。
J Biol Chem. 1984 Jun 10;259(11):7115-22.
8
S-Adenosyl-L-homocysteine hydrolase: analogues of S-adenosyl-L-homocysteine as potential inhibitors.S-腺苷-L-高半胱氨酸水解酶：作为潜在抑制剂的S-腺苷-L-高半胱氨酸类似物
Mol Pharmacol. 1977 Sep;13(5):939-47.
9
Protein-O-carboxylmethyltransferase from cytosol and membranes of chicken erythrocytes.来自鸡红细胞胞质溶胶和细胞膜的蛋白质-O-羧甲基转移酶。
J Biochem. 1987 Aug;102(2):319-26. doi: 10.1093/oxfordjournals.jbchem.a122057.
10
Inhibition of calf thymus and rat hypothalamic synaptosomal protein carboxymethyltransferase by analogues of S-adenosylhomocysteine.S-腺苷高半胱氨酸类似物对小牛胸腺和大鼠下丘脑突触体蛋白羧甲基转移酶的抑制作用。
Mol Pharmacol. 1982 Jan;21(1):181-6.

引用本文的文献

1
Synthesis and characterization of -adenosyl-L-selenohomocysteine selenoxide.-腺苷-L-硒代高半胱氨酸亚硒酸盐的合成与表征
J Sulphur Chem. 2015 Apr 1;36(2):135-144. doi: 10.1080/17415993.2014.979173.

本文引用的文献

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Direct halogenation of sugar moiety of nucleosides.核苷糖部分的直接卤化。
Tetrahedron Lett. 1971 Jan(2):87-90. doi: 10.1016/s0040-4039(01)96366-x.
2
Potential inhibitor of S-adenosylmethionine-dependent methyltransferases. 2. Modification of the base portion of S-adenosylhomocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。2. S-腺苷同型半胱氨酸碱基部分的修饰。
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 1. Modification of the amino acid portion of S-adenosylhomocysteine.
S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。1. S-腺苷高半胱氨酸氨基酸部分的修饰。
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Purification and properties of protein methylase II.
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[Inhibition of a t-RNA N 2 -guanine methyl transferase from rabbit liver by analogs of S-adenosyl homocysteine].[S-腺苷同型半胱氨酸类似物对兔肝t-RNA N2-鸟嘌呤甲基转移酶的抑制作用]
Biochimie. 1972;54(8):989-95. doi: 10.1016/s0300-9084(72)80049-x.
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。3. S-腺苷同型半胱氨酸糖部分的修饰。
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 6. Structural modifications of S-adenosylmethionine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。6. S-腺苷甲硫氨酸的结构修饰。
J Med Chem. 1976 Sep;19(9):1104-10. doi: 10.1021/jm00231a005.
8
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 5. Role of the asymmetric sulfonium pole in the enzymatic binding of S-adenosyl-L-methionine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。5. 不对称锍极在S-腺苷-L-甲硫氨酸酶促结合中的作用。
J Med Chem. 1976 Sep;19(9):1099-1103. doi: 10.1021/jm00231a004.
9
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 4. Further modifications of the amino and base portions of S-adenosyl-L-homocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。4. S-腺苷-L-高半胱氨酸氨基和碱基部分的进一步修饰。
J Med Chem. 1976 Sep;19(9):1094-9. doi: 10.1021/jm00231a003.
10
Labile protein-methyl ester: comparison between chemically and enzymatically synthesized.
Experientia. 1976 Aug 15;32(8):982-4. doi: 10.1007/BF01933924.