Suppr超能文献

甲状腺切除动物的免疫抑制

Immunodepression in thyroid-deprived animals.

作者信息

Fabris N

出版信息

Clin Exp Immunol. 1973 Dec;15(4):601-11.

PMID:4778719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553975/
Abstract

The removal of the thyroid gland in newborn or in young adult rats causes reduction in the number of peripheral blood lymphocytes and depression of either the humoral immune reactions against sheep and chicken red blood cells or the response of spleen cells to phytohaemagglutinin. These immunological defects are fully established in perinatally thyroidectomized rats after weaning, while in animals thyroidectomized in young-adult age they are observable 45–60 days after the operation. In both cases daily injections with thyroxine can completely restore the lymphoid system of thyroid-deprived animals. These results stress the importance of thyroid hormones for lymphocyte proliferation either during the period of ontogenetic development or in adult life.

摘要

切除新生或幼年成年大鼠的甲状腺会导致外周血淋巴细胞数量减少，以及针对绵羊和鸡红细胞的体液免疫反应或脾细胞对植物血凝素的反应受到抑制。这些免疫缺陷在围产期甲状腺切除的大鼠断奶后完全形成，而在成年期甲状腺切除的动物中，术后45 - 60天可观察到这些缺陷。在这两种情况下，每天注射甲状腺素都能完全恢复甲状腺缺失动物的淋巴系统。这些结果强调了甲状腺激素在个体发育期间或成年生活中对淋巴细胞增殖的重要性。

相似文献

1
Immunodepression in thyroid-deprived animals.甲状腺切除动物的免疫抑制
Clin Exp Immunol. 1973 Dec;15(4):601-11.
2
Experimental studies on the effect of phytohemagglutinin on the immune response in mice.
Nihon Ketsueki Gakkai Zasshi. 1970 Jun;33(3):299-311.
3
Divergent selection of chickens for antibody production to sheep erythrocytes: age effect in parental lines and their crosses.针对绵羊红细胞抗体产生对鸡进行的 divergent 选择：亲本品系及其杂交后代的年龄效应 。 注：“divergent”这里不太明确准确意思，可结合上下文进一步理解准确含义，可能是“不同方向的”“分化的”等意思 。
Avian Dis. 1985 Jan-Mar;29(1):150-8.
4
Nutrition and immunological responsiveness. T-cell function in the offspring of lipotrope and protein-deficient rats.营养与免疫反应性。低脂血症和蛋白质缺乏大鼠后代的T细胞功能。
Immunology. 1974 Mar;26(3):489-95.
5
In vitro studies of chicken lymphoid cells. II. The anamnestic response of spleen cells from control-irradiated and bursectomized-irradiated chickens to sheep erythrocytes.鸡淋巴细胞的体外研究。II. 对照照射和法氏囊切除照射鸡的脾细胞对绵羊红细胞的回忆反应。
Int Arch Allergy Appl Immunol. 1971;40(4-5):643-55.
6
Effect of simulated weightlessness on the immune system in rats.模拟失重对大鼠免疫系统的影响。
Aviat Space Environ Med. 1980 Mar;51(3):251-5.
7
Comparison of the effect of antilymphocyte globulins against cells of normal and immunized rats on antibody formation to red blood cells.抗淋巴细胞球蛋白对正常大鼠和免疫大鼠细胞的作用在针对红细胞抗体形成方面的比较。
Folia Biol (Praha). 1973;19(6):433-42.
8
The relationship between antibody formation and deoxyribonucleic acid (DNA) synthesis in mouse spleen during primary and secondary response to sheep erythrocytes (SRC).在对绵羊红细胞（SRC）的初次和二次应答过程中，小鼠脾脏中抗体形成与脱氧核糖核酸（DNA）合成之间的关系。
Immunology. 1972 Aug;23(2):183-97.
9
[Hyperplasia of lymphatic ganglia and spleen after immunization against sheep erythrocytes and comparative participation of thymus-dependent lymphocytes to hyperplasia in protein-deficient and non-deficient rats].[绵羊红细胞免疫后淋巴节和脾脏的增生以及蛋白质缺乏和非缺乏大鼠中胸腺依赖性淋巴细胞对增生的比较参与情况]
Ann Nutr Aliment. 1973;27(3):147-61.
10
Endotoxin-mediated decrease in content of RNA, DNA, and protein of spleen and lymph nodes in neonatally thymectomized rats immunized with sheep erythrocytes.内毒素介导的新生期胸腺切除并用绵羊红细胞免疫的大鼠脾脏和淋巴结中RNA、DNA及蛋白质含量的降低。
Ann Immunol Hung. 1973;17:suppl 35-40.

引用本文的文献

1
Association between thymic hyperplasia and serum calcium level in Graves' disease.格雷夫斯病患者胸腺增生与血清钙水平的相关性。
BMC Endocr Disord. 2024 Jan 29;24(1):15. doi: 10.1186/s12902-024-01541-4.
2
Identification of a pharyngeal mucosal lymphoid organ in zebrafish and other teleosts: Tonsils in fish?斑马鱼和其他硬骨鱼咽部黏膜淋巴器官的鉴定：鱼类的扁桃体？
Sci Adv. 2023 Nov 3;9(44):eadj0101. doi: 10.1126/sciadv.adj0101. Epub 2023 Nov 1.
3
The Impact of Kohlrabi Sprouts on Various Thyroid Parameters in Iodine Deficiency- and Sulfadimethoxine-Induced Hypothyroid Rats.芜菁芽对碘缺乏和磺胺二甲氧嘧啶诱导的甲状腺功能减退大鼠各种甲状腺参数的影响。
Nutrients. 2022 Jul 8;14(14):2802. doi: 10.3390/nu14142802.
4
Immunological Drivers in Graves' Disease: NK Cells as a Master Switcher.格雷夫斯病中的免疫驱动因素：NK 细胞作为主开关。
Front Endocrinol (Lausanne). 2020 Jul 17;11:406. doi: 10.3389/fendo.2020.00406. eCollection 2020.
5
The long-term oral administration of thyroxine: effects on blood hematological and biochemical features in broiler breeder hens.长期口服甲状腺素：对肉种鸡母鸡血液血液学和生化学特征的影响。
Poult Sci. 2019 Dec 1;98(12):7003-7008. doi: 10.3382/ps/pez331.
6
Lactation and resource limitation affect stress responses, thyroid hormones, immune function, and antioxidant capacity of sea otters ().哺乳期和资源限制会影响海獭的应激反应、甲状腺激素、免疫功能和抗氧化能力。
Ecol Evol. 2018 Jul 25;8(16):8433-8447. doi: 10.1002/ece3.4280. eCollection 2018 Aug.
7
Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity.伴有促甲状腺素受体胸腺表达的格雷夫斯病患者及胸腺增生的动态变化与格雷夫斯病活动度成比例
Yonsei Med J. 2016 May;57(3):795-8. doi: 10.3349/ymj.2016.57.3.795.
8
Thymic hyperplasia in patients with Graves' disease.格雷夫斯病患者的胸腺增生。
J Endocrinol Invest. 2014 Dec;37(12):1175-9. doi: 10.1007/s40618-014-0157-7. Epub 2014 Aug 23.
9
Enhanced chemotaxis of macrophages by strenuous exercise in trained mice: thyroid hormones as possible mediators.训练有素的小鼠通过剧烈运动增强巨噬细胞的趋化作用：甲状腺激素可能作为介质
Mol Cell Biochem. 1999 Nov;201(1-2):41-7. doi: 10.1023/a:1007020804138.
10
Thymic hyperplasia in patients with Graves' disease. Identification of thyrotropin receptors in human thymus.格雷夫斯病患者的胸腺增生。人胸腺中促甲状腺激素受体的鉴定。
J Clin Invest. 1996 Nov 15;98(10):2228-34. doi: 10.1172/JCI119032.

本文引用的文献

1
The occurrence of lymphoma in patients with long-standing hyperthyroidism.长期甲状腺功能亢进患者中淋巴瘤的发生情况。
Blood. 1963 Mar;21:282-97.
2
Thymic and thoracic duct contributions to blood lymphocytes in normal and thyroxin-treated guinea-pigs.胸腺和胸导管对正常及甲状腺素处理的豚鼠血液淋巴细胞的作用。
Acta Physiol Scand. 1966 Jan-Feb;66(1):189-95. doi: 10.1111/j.1748-1716.1966.tb03184.x.
3
Hormones and the immunological capacity. IV. Restorative effects of developmental hormones or of lymphocytes on the immunodeficiency syndrome of the dwarf mouse.激素与免疫能力。IV. 发育激素或淋巴细胞对侏儒小鼠免疫缺陷综合征的恢复作用。
Clin Exp Immunol. 1971 Aug;9(2):227-40.
4
Hormones and the immunological capacity. 3. The immunodeficiency disease of the hypopituitary Snell-Bagg dwarf mouse.激素与免疫能力。3. 垂体功能减退的斯内尔-巴格侏儒小鼠的免疫缺陷疾病。
Clin Exp Immunol. 1971 Aug;9(2):209-25.
5
A thymus dependent function of the adrenal cortex and its relation to immunity.肾上腺皮质的胸腺依赖性功能及其与免疫的关系。
Experientia. 1972 Jul 15;28(7):851-2. doi: 10.1007/BF01923171.
6
Lymphocytes, hormones and ageing.淋巴细胞、激素与衰老。
Nature. 1972 Dec 29;240(5383):557-9. doi: 10.1038/240557a0.
7
Role for protein phosphorylation in meiosis and in the early cleavage phase of amphibian embryonic development.蛋白质磷酸化在两栖类胚胎发育的减数分裂和早期卵裂阶段中的作用。
Nature. 1972 Aug 4;238(5362):282-4. doi: 10.1038/238282a0.
8
Developmental hormones and immunological maturation.发育激素与免疫成熟
Ciba Found Study Group. 1970;36:126-53.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验