Gebhardt B M, Newberne P M
Immunology. 1974 Mar;26(3):489-95.
The progeny of mothers subjected to marginal lipotrope or moderately low protein diets exhibit deficient humoral immune responses. Serum antibody titres and numbers of antibody-forming cells to sheep erythrocytes (SRBC) are lower in the offspring of mothers whose diets were limited in either percentage protein or percentage lipotropes than in offspring whose mothers were fed a complete diet. Immune lymphocyte stimulation by SRBC antigens was marginal and not measurably different between the progeny of malnourished mothers and controls. The response of spleen cells from offspring of nutritionally deprived mothers to the T-cell mitogen phytohaemagglutinin (PHA) is considerably less than that of controls. Thymus cells from marginal lipotrope offspring respond well to PHA, suggesting that PHA-reactive cell migration may be inhibited in these animals. These results, obtained using a T-dependent antigen (SRBC) and a T-dependent mitogen (PHA), support the conclusion that maternal dietary deficiency can adversely affect T-cell function in rat offspring.
接受边缘性促脂物质或适度低蛋白饮食的母亲所生后代，其体液免疫反应存在缺陷。与喂食完全日粮的母亲所生后代相比，日粮中蛋白质百分比或促脂物质百分比受限的母亲所生后代，其针对绵羊红细胞（SRBC）的血清抗体滴度和抗体形成细胞数量较低。SRBC抗原对免疫淋巴细胞的刺激作用微弱，营养不良母亲的后代与对照组之间无明显差异。营养缺乏母亲所生后代的脾细胞对T细胞丝裂原植物血凝素（PHA）的反应明显低于对照组。边缘性促脂物质缺乏后代的胸腺细胞对PHA反应良好，这表明这些动物中PHA反应性细胞的迁移可能受到抑制。这些使用T依赖性抗原（SRBC）和T依赖性丝裂原（PHA）获得的结果支持了这样的结论，即母体饮食缺乏会对大鼠后代的T细胞功能产生不利影响。
