Uzbekova D G
Farmakol Toksikol. 1979 Jul-Aug;42(4):354-8.
Distribution of intramuscular and oral aminazin (20 mg/kg) in the brain, lungs, liver, kidneys, heart, ileum, blood and urine was studied in young and old male rats. Intramuscular drug showed maximal accumulation in the lungs and intestine, respectively, whereas at oral administration maximal and minimal accumulation was recorded in the liver and kidneys. Urine excretion of parenteral aminazin was 4-7-fold higher as compared to oral administration. Delayed accumulation of aminazin in the organs and its decreased excretion with urine were recorded in old animals.
研究了年轻和老年雄性大鼠脑、肺、肝、肾、心脏、回肠、血液和尿液中肌肉注射及口服氯丙嗪（20毫克/千克）的分布情况。肌肉注射药物分别在肺和肠道中显示出最大蓄积，而口服给药时，在肝脏和肾脏中记录到最大和最小蓄积。与口服给药相比，肠胃外氯丙嗪的尿液排泄量高4至7倍。在老年动物中记录到氯丙嗪在器官中的蓄积延迟及其随尿液排泄的减少。
