Gavrilov E M, Zhaugasheva S K, Shchepetkina L V
Farmakol Toksikol. 1986 Jan-Feb;49(1):69-71.
The distribution of monomycin (15 mg/kg intramuscularly) in the blood serum and organs of mature, old and young rats was studied in the agar diffusion test. Bact. pumelis was used as test microorganism. The good absorption of this antibiotic into blood was revealed and its accumulation in high concentrations in the kidneys of animals of all ages, that conditions to a certain degree the nephrotoxicity of the preparation. Its accumulation in the organs and release from them is quicker in young rats than in mature and old ones. According to monomycin concentration, the organs were distributed in the following descending order: kidneys-liver-lungs-spleen.
在琼脂扩散试验中研究了单霉素（15毫克/千克肌肉注射）在成熟、老龄和幼年大鼠血清及器官中的分布情况。短小芽孢杆菌用作测试微生物。结果显示该抗生素在血液中吸收良好，且在各年龄段动物的肾脏中高浓度蓄积，这在一定程度上导致了该制剂的肾毒性。幼年大鼠体内该抗生素在器官中的蓄积及从器官中的释放比成熟和老龄大鼠更快。根据单霉素浓度，各器官的分布顺序如下：肾脏-肝脏-肺-脾脏。
