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[钾离子对肾动脉平滑肌收缩活性的影响]

[Effect of potassium ions on the contractile activity of renal artery smooth muscle].

作者信息

Orlov R S, Aĭvar Iu P

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1979 Jul;65(7):1040-5.

PMID:478020
Abstract

Study of isolated segments of renal arteries in rabbits showed that decrease of potassium ion concentration in the bathing fluid was followed by increase in tension, while its increase from 5 meq/l to 10 meq/l was accompanied by gradual relaxation of vessel muscles and increase of their sensitivity to noradrenalin (NA). This relationship was lacking in segments activated with NA. The ability of NA and angiotensin to activate renal arterial muscles by electromechanic and pharmacomechanic coupling mechanismes was proved experimentally. The paper discussed the role of the cell membrane sodium potassium pump in vascular muscles.

摘要

对兔肾动脉分离段的研究表明,浴液中钾离子浓度降低后张力增加,而钾离子浓度从5毫当量/升增加到10毫当量/升时,血管肌肉逐渐松弛,且对去甲肾上腺素(NA)的敏感性增加。在用NA激活的血管段中不存在这种关系。实验证明了NA和血管紧张素通过机电偶联和药理机械偶联机制激活肾动脉肌肉的能力。本文讨论了细胞膜钠钾泵在血管肌肉中的作用。

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