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[处于不同应激状态下生长的大鼠血液及肌肉中胆固醇与卵磷脂含量及其与生理指标的相关性]

[Correlation between cholesterol and lecithin in the blood and muscles and physiologic indices in rats developing in various stress states].

作者信息

Arshavskiĭ I A, Rozanova V D, Shaĭkemeleva U S

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1979 Jul;65(7):970-8.

PMID:478032
Abstract

Development female rats during the 1st year of life, under conditions of dynamic exercises caused starting from the 4th month, a decrease in the blood cholesterin and the raise of lecithin and lecithin--cholesterin index (L/Ch). No hypercholesterinemia common for the control animals develops by the 13th month in these animals. The cholesterin content increases in their muscles. Static loads launch less beneficent shifts of the above parameters. These rats reveal larger amount of the blood cholesterin along with its decrease in the muscles by the end of the 1st year. Under nociceptive effects the rats develop hypercholesterinemia and hypolecithinemia yet by the 7th month which accounts for a sharply reduced L/Ch index. At 13 months cholesterin is obviously decreased in the muscles of these rats. Resting energy expenditure is increased in these rats due to activated thyroid function and to a decrease in the cholinergic maintenance of regulation.

摘要

在生命的第一年,处于动态运动条件下的发育中的雌性大鼠,从第4个月开始,血液胆固醇降低,卵磷脂及卵磷脂 - 胆固醇指数(L/Ch)升高。到第13个月时,这些动物未出现对照动物常见的高胆固醇血症。它们肌肉中的胆固醇含量增加。静态负荷引发上述参数的有益变化较少。这些大鼠在1岁末时血液胆固醇含量增加,同时肌肉中胆固醇含量降低。在伤害性刺激作用下,大鼠在第7个月时就出现高胆固醇血症和低卵磷脂血症,这导致L/Ch指数急剧降低。在13个月时,这些大鼠肌肉中的胆固醇明显降低。由于甲状腺功能激活以及调节的胆碱能维持作用降低,这些大鼠的静息能量消耗增加。

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