Jacoby H I, Bonfilio A C, Gray S, Staus A, Thomas C
Digestion. 1979;19(4):237-43. doi: 10.1159/000198351.
The effect of aminophylline on gastric acid secretion has been studied in the rat and dog. Aminophylline was shown to possess antisecretory activity when given either by oral or parenteral administration in an acute gastric fistula rat preparation. In the chronic gastric fistula dog aminophylline at 50 mg/kg intragastrically induced a small but significant stimulation of basal acid secretion. This dose of aminophylline also significantly inhibited acid secretion induced by gastrin tetrapeptide, and 2-deoxy-D-glucose but did not block acid secretion induced by histamine.
已经在大鼠和狗身上研究了氨茶碱对胃酸分泌的影响。在急性胃瘘大鼠制备中，经口服或肠胃外给药时，氨茶碱显示出抗分泌活性。在慢性胃瘘狗中，胃内给予50mg/kg氨茶碱可引起基础胃酸分泌的轻微但显著的刺激。该剂量的氨茶碱还显著抑制了由胃泌素四肽和2-脱氧-D-葡萄糖诱导的胃酸分泌，但不阻断由组胺诱导的胃酸分泌。
