Soldani G, Del Tacca M, Polloni A, Bernardini C, Martinotti E
Int J Tissue React. 1984;6(2):181-4.
The antisecretory potency of oxmetidine was compared with that of ranitidine for its action against gastric acid secretion induced by histamine and by 2-deoxy-D-glucose (2DG) in the conscious gastric-fistula dog. Oxmetidine, administered i.v. during histamine stimulation, was nearly as effective as ranitidine, with a similar duration of action, but it was about twice as potent as ranitidine against 2DG-stimulated acid secretion. In experiments with bombesin, both oxmetidine and ranitidine significantly decreased gastric acid secretion to a similar extent, without affecting plasma gastrin levels.
在清醒胃瘘犬中，比较了奥美替丁与雷尼替丁对组胺和2-脱氧-D-葡萄糖（2DG）诱导的胃酸分泌的抑制作用。在组胺刺激期间静脉注射奥美替丁，其效果与雷尼替丁相近，作用持续时间相似，但在抑制2DG刺激的胃酸分泌方面，奥美替丁的效力约为雷尼替丁的两倍。在用蛙皮素进行的实验中，奥美替丁和雷尼替丁均能显著降低胃酸分泌，且降低程度相似，同时不影响血浆胃泌素水平。
