封闭用特定蛋白质抗原鉴定出的T淋巴细胞表面的抗原-抗体复合物。II. 体外反应过程中的淋巴细胞活化。
Blocking antigen-antibody complexes on the T-lymphocye surface identified with defined protein antigens. II. Lymphocyte activation during the in vitro response.
作者信息
Kontiainen S
出版信息
Immunology. 1975 Mar;28(3):535-42.
Abstract
Antibody-forming cells against DNP (DNP-AFC) appear in nonantigen-stimulated cultures of spleen cells from mice which were boosted with antigen DNP-CGG or TNP-KLH in saline several weeks before the vitro cultures were started. The similar kinetics of the appearance of DNP-AFC in antigen-stimulated and non-antigen-stimulated cultures suggests that new B cells were triggered during the in vitro culture. The data supporting the concept of antigen being retained in the body for long periods of time in the form of antigen-antibody complexes on the T-cell surface is discussed.
摘要
在体外培养开始前几周，用抗原二硝基苯基-鸡γ球蛋白（DNP-CGG）或三硝基苯基-钥孔戚血蓝蛋白（TNP-KLH）生理盐水溶液对小鼠进行加强免疫，然后从小鼠脾脏细胞的非抗原刺激培养物中出现了抗二硝基苯基抗体形成细胞（DNP-AFC）。在抗原刺激和非抗原刺激培养物中DNP-AFC出现的相似动力学表明，在体外培养期间新的B细胞被触发。文中讨论了支持抗原以抗原-抗体复合物形式长时间保留在体内T细胞表面这一概念的数据。
相似文献
1
2
3
Non-specific factor replaces T cells in an IgG response to soluble antigens.在对可溶性抗原的IgG应答中，非特异性因子替代了T细胞。
Immunology. 1977 Sep;33(3):321-9.
4
5
6
T cell tolerization in vitro: modulation of helper and suppressor cell activities.体外T细胞耐受诱导：辅助性和抑制性细胞活性的调节
J Immunol. 1987 Jul 15;139(2):338-45.
7
Priming or tolerization of the B- and Th2-dependent immune response by the oral administration of OVA-DNP is determined by the antigen dosage.通过口服卵清蛋白-二硝基苯（OVA-DNP）引发或诱导B细胞和Th2细胞依赖性免疫反应取决于抗原剂量。
Cell Immunol. 1998 Nov 25;190(1):1-11. doi: 10.1006/cimm.1998.1356.
8
Clonal dominance and the preservation of clonal memory cells mediated by antigen-antibody.克隆优势以及由抗原-抗体介导的克隆记忆细胞的保存。
Immunology. 1976 Oct;31(4):541-51.
9
B-memory cells can be stimulated by antigen in vitro to become IgG antibody-secreting cells.B记忆细胞可在体外被抗原刺激，从而成为分泌IgG抗体的细胞。
Immunology. 1977 May;32(5):771-6.
引用本文的文献
1
Pathopysiological aspects of immune complex diseases. Part II. Phagocytosis, exocytosis, and pathogenic depositions.免疫复合物疾病的病理生理学方面。第二部分。吞噬作用、胞吐作用和致病性沉积。
Klin Wochenschr. 1980 Jun 16;58(12):593-605. doi: 10.1007/BF01477835.
2
Clinical relevance of circulating immune complexes in human leukemia. Association in acute leukemia of the presence of immune complexes with unfavorable prognosis.循环免疫复合物在人类白血病中的临床相关性。免疫复合物的存在与急性白血病不良预后的关联。
J Clin Invest. 1977 Oct;60(4):874-84. doi: 10.1172/JCI108842.
3
Aberrant secondary antibody responses to sheep erythrocytes in rabbits with experimental syphilis.实验性梅毒兔对绵羊红细胞的异常二次抗体反应。
Infect Immun. 1979 Jul;25(1):133-8. doi: 10.1128/iai.25.1.133-138.1979.
本文引用的文献
1
PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES.纯化抗2,4-二硝基苯基抗体的制备
Methods Med Res. 1964;10:94-102.
2
A requirement for two cell types for antibody formation in vitro.体外抗体形成需要两种细胞类型。
Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.
3
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
4
Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.体外免疫应答中的细胞相互作用。IV. 抗原特异性和同种异体胸腺衍生细胞因子作用的比较。
J Exp Med. 1972 Oct 1;136(4):722-36. doi: 10.1084/jem.136.4.722.
5
The separation of different cell classes from lymphoid organs. IV. The separation of lymphocytes from phagocytes on glass bead columns, and its effect on subpopulations of lymphocytes and antibody-forming cells.从淋巴器官中分离不同细胞类型。IV. 在玻璃珠柱上从吞噬细胞中分离淋巴细胞及其对淋巴细胞亚群和抗体形成细胞的影响。
J Cell Biol. 1971 Mar;48(3):566-79. doi: 10.1083/jcb.48.3.566.
6
Unmasking of cell-associated foreign antigens during incubation of lymphoid cells.淋巴细胞孵育过程中细胞相关外来抗原的暴露
Isr J Med Sci. 1969 Mar-Apr;5(2):230-4.
7
Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages.耐受性、增强作用以及T细胞、B细胞与巨噬细胞之间相互作用的调节
Transplant Rev. 1972;13:3-34. doi: 10.1111/j.1600-065x.1972.tb00058.x.
8
Antigen--antibody complexes as blocking factors on the T lymphocyte surface.抗原-抗体复合物作为T淋巴细胞表面的封闭因子。
Soc Gen Physiol Ser. 1974;29:143-54.
Zotero 插件