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体外抗体形成需要两种细胞类型。

A requirement for two cell types for antibody formation in vitro.

作者信息

Mosier D E

出版信息

Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.

DOI:10.1126/science.158.3808.1573
PMID:6060362
Abstract

A suspension of mouse spleen cells can be separated into two populations on the basis of their ability or inability to adhere to plastic dishes. It was found that both adherent and nonadherent cells were necessary for the induction of antibody formation to sheep red blood cells in vitro. Exposure of adherent cells to antigen for brief periods of time was sufficient to initiate a maximal in vitro response.

摘要

小鼠脾细胞悬液可根据其能否黏附于塑料培养皿分为两类细胞群。研究发现，在体外诱导针对绵羊红细胞的抗体形成时，贴壁细胞和非贴壁细胞都是必需的。将贴壁细胞短时间暴露于抗原足以引发最大程度的体外反应。

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1
A requirement for two cell types for antibody formation in vitro.体外抗体形成需要两种细胞类型。
Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.
2
X-ray resistant cell required for the induction of in vitro antibody formation.诱导体外抗体形成所需的耐X射线细胞。
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[Structure and function of antibody producing cells of the mouse during the early immune response].[小鼠早期免疫应答期间抗体产生细胞的结构与功能]
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Functional and ultrastructural studies of antibody-producing cells exposed to 10,000 R in millipore diffusion chambers.在微孔扩散小室中暴露于10000伦琴的抗体产生细胞的功能和超微结构研究。
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In vivo requirement for a radiation-resistant cells in the immune response to sheep erythrocytes.对绵羊红细胞免疫应答中抗辐射细胞的体内需求。
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Participation of three cell types in the anti-sheep red blood cell response in vitro. Separation of antigen-reactive cells from the precursors of antibody-forming cells.三种细胞类型参与体外抗绵羊红细胞反应。从抗体形成细胞前体中分离抗原反应性细胞。
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Immune response in vitro: independence of "activated" lymphoid cells.体外免疫反应：“活化”淋巴细胞的独立性
Science. 1969 Nov 21;166(3908):1002-4. doi: 10.1126/science.166.3908.1002.

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