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半乳糖代谢中的性别差异:小鼠肾脏中的半乳糖基神经酰胺半乳糖苷酶及其他半乳糖苷酶

Sexual differences in galactose metabolism: galactosyl ceramide galactosidase and other galactosidases in mouse kidney.

作者信息

Lin Y N, Radin N S

出版信息

Biochem J. 1973 Dec;136(4):1125-7. doi: 10.1042/bj1361125.

DOI:10.1042/bj1361125
PMID:4786533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166066/
Abstract

Male and female mice were compared at two ages, 15 and 50 days, with respect to the activities of three galactosidases in kidney. No sex difference in enzyme activity was seen in the young mice, but appreciable differences were found in the older animals. The male kidneys had about one-third higher specific activities of cerebroside beta-galactosidase and nitrophenyl beta-galactosidase, but there was no difference with nitrophenyl alpha-galactosidase. A listing and discussion of other galactose-metabolizing enzymes influenced by sex differences is presented.

摘要

对15日龄和50日龄的雄性和雌性小鼠肾脏中的三种半乳糖苷酶活性进行了比较。在幼龄小鼠中未观察到酶活性的性别差异,但在老龄动物中发现了明显差异。雄性小鼠肾脏中脑苷脂β - 半乳糖苷酶和硝基苯基β - 半乳糖苷酶的比活性高出约三分之一,但硝基苯基α - 半乳糖苷酶没有差异。本文列出并讨论了受性别差异影响的其他半乳糖代谢酶。

相似文献

1
Sexual differences in galactose metabolism: galactosyl ceramide galactosidase and other galactosidases in mouse kidney.半乳糖代谢中的性别差异:小鼠肾脏中的半乳糖基神经酰胺半乳糖苷酶及其他半乳糖苷酶
Biochem J. 1973 Dec;136(4):1125-7. doi: 10.1042/bj1361125.
2
Human kidney alpha-galactosidase. Multiplicity and enzyme activities for ceramide trihexoside and some aryl alpha-galactosides.人肾α-半乳糖苷酶。神经酰胺三己糖苷和一些芳基α-半乳糖苷的多样性及酶活性。
J Biochem. 1974 Feb;75(2):347-54. doi: 10.1093/oxfordjournals.jbchem.a130401.
3
Cerebroside galactosidase of brain.脑苷脂半乳糖苷酶(存在于脑内)
J Lipid Res. 1966 May;7(3):379-86.
4
Studies on galactosyl ceramide and lactosyl ceramide beta-galactosidase.
Chem Phys Lipids. 1974 Dec;13(4):327-9. doi: 10.1016/0009-3084(74)90007-3.
5
Generalized gangliosidosis: beta-galactosidase deficiency.全身性神经节苷脂沉积症:β-半乳糖苷酶缺乏症。
Science. 1968 May 31;160(3831):1002-4. doi: 10.1126/science.160.3831.1002.
6
The inhibitor-sensitive sites of galactosyl ceramide galactosidase.半乳糖基神经酰胺半乳糖苷酶的抑制剂敏感位点。
Arch Biochem Biophys. 1973 May;156(1):77-83. doi: 10.1016/0003-9861(73)90343-3.
7
A simplified assay method for galactosyl ceramide beta-galactosidase.
J Lipid Res. 1971 Mar;12(2):256-7.
8
Mendelian inheritance of variations in beta-galactosidase activities in the house mouse.家鼠中β-半乳糖苷酶活性变异的孟德尔遗传
Biochem Genet. 1973 Dec;10(4):351-61. doi: 10.1007/BF00485990.
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Purification of cerebroside galactosidase from rat brain.
Biochim Biophys Acta. 1968 May 1;152(3):587-98. doi: 10.1016/0005-2760(68)90099-4.
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Investigation of the alpha-galactosidase deficiency in Fabry's disease using antibodies against the purified enzyme.使用针对纯化酶的抗体对法布里病中的α-半乳糖苷酶缺乏症进行研究。
Eur J Biochem. 1974 Jul 1;46(1):89-98. doi: 10.1111/j.1432-1033.1974.tb03600.x.

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本文引用的文献

1
Progesterone effects on galactose metabolism in prepubertal patients with congenital galactosemia and in rats maintained on high galactose diets.孕酮对青春期前先天性半乳糖血症患者以及高半乳糖饮食喂养大鼠的半乳糖代谢的影响。
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Effects of steroids upon galactose oxidation in vitro.
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Response of sphingolipid hydrolases in spleen and liver to increased erythrocytorhexis.
Biochim Biophys Acta. 1967 Feb 14;137(1):135-9. doi: 10.1016/0005-2760(67)90016-1.
4
Cerebroside galactosidase of brain.脑苷脂半乳糖苷酶(存在于脑内)
J Lipid Res. 1966 May;7(3):379-86.
5
Endocrine modification of the developmental formation of ornithine aminotransferase in rat tissues.大鼠组织中鸟氨酸氨基转移酶发育形成的内分泌调节。
J Biol Chem. 1969 Sep 25;244(18):4894-8.
6
Cerebroside galactosidase: a method for determination and a comparison with other lysosomal enzymes in developing rat brain.脑苷脂半乳糖苷酶:发育中大鼠脑内的一种测定方法及与其他溶酶体酶的比较
J Neurochem. 1969 Apr;16(4):501-11. doi: 10.1111/j.1471-4159.1969.tb06849.x.
7
A simplified assay method for galactosyl ceramide beta-galactosidase.
J Lipid Res. 1971 Mar;12(2):256-7.
8
Glycosphingolipid biosynthesis in kidneys of normal C3H-He mice and of those with BP8 ascites tumours.正常C3H-He小鼠以及患有BP8腹水瘤小鼠肾脏中的糖鞘脂生物合成。
Biochem Biophys Res Commun. 1970 Feb 6;38(3):527-32. doi: 10.1016/0006-291x(70)90746-1.
9
The biosynthesis of digalactosylceramide in the kidney of the C57-BL mouse.C57-BL小鼠肾脏中双半乳糖神经酰胺的生物合成。
Biochem Biophys Res Commun. 1970 Feb 6;38(3):520-6. doi: 10.1016/0006-291x(70)90745-x.
10
Human urinary sulfatides in patients with sulfatidosis (metachromatic leukodystrophy).硫脂贮积症(异染性脑白质营养不良)患者的人尿硫脂
J Lipid Res. 1971 Jul;12(4):434-41.