Franklin R M, Prendergast R A, Silverstein A M
Invest Ophthalmol Vis Sci. 1979 Oct;18(10):1093-6.
A distinct system of immunity in a variety of animals is located subjacent to epithelial surfaces and is typified by the predominance of immunoglobulin A (IgA) and secretory component (SC) in various external secretions, including tears. The present study examined normal rabbit lacrimal gland, conjunctiva, and cornea for the presence of immunoglobulin and SC. IgA-staining plasma cells predominated within lacrimal gland and conjunctival stroma, and SC was found in the epithelial cells of both these tissues but not within corneal epithelium. These observations are consistent with findings for other secretory sites in both rabbits and humans and establish lacrimal gland and conjunctiva as integral parts of the rabbit secretory immune system.
多种动物中一种独特的免疫系统位于上皮表面下方，其典型特征是在包括眼泪在内的各种外分泌液中免疫球蛋白A（IgA）和分泌成分（SC）占主导地位。本研究检测了正常兔泪腺、结膜和角膜中免疫球蛋白和SC的存在情况。IgA染色的浆细胞在泪腺和结膜基质中占主导，并且在这两种组织的上皮细胞中发现了SC，但在角膜上皮中未发现。这些观察结果与兔和人类其他分泌部位的研究结果一致，并将泪腺和结膜确立为兔分泌免疫系统的组成部分。
