在具有河豚毒素抗性动作电位的肠肌间神经丛神经元中，钙依赖性慢后超极化。
The calcium-dependent slow after-hyperpolarization in myenteric plexus neurones with tetrodotoxin-resistant action potentials.
作者信息
North R A
出版信息
Br J Pharmacol. 1973 Dec;49(4):709-11. doi: 10.1111/j.1476-5381.1973.tb08550.x.
Abstract
Intracellular recordings were made from neurones of the myenteric plexus of the guinea-pig ileum. The slow after-hyperpolarization which followed an action potential in some neurones was abolished by Mn(++), La(+++) and by solutions which contained no Ca(++). In these neurones, the action potential and the slow after-hyperpolarization persisted in Na(+)-free solutions or in the presence of tetrodotoxin (2 muM). The findings suggest that an inward Ca(++) current during the action potential is essential for the slow after-hyperpolarization.
摘要
从豚鼠回肠肌间神经丛的神经元进行细胞内记录。某些神经元动作电位之后出现的缓慢超极化后电位被锰离子（Mn++）、镧离子（La+++）以及不含钙离子（Ca++）的溶液所消除。在这些神经元中，动作电位和缓慢超极化后电位在无钠离子溶液或存在河豚毒素（2微摩尔）的情况下依然存在。这些发现表明，动作电位期间的内向钙离子电流对于缓慢超极化后电位至关重要。
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1
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Nat New Biol. 1973 May 9;243(123):54-6.
2
Injections of calcium ions into spinal motoneurones.向脊髓运动神经元注射钙离子。
J Physiol. 1972 Sep;225(2):363-90. doi: 10.1113/jphysiol.1972.sp009945.
3
Intracellular recording from the myenteric plexus of the guinea-pig ileum.豚鼠回肠肌间神经丛的细胞内记录。
J Physiol. 1973 Jun;231(3):471-91. doi: 10.1113/jphysiol.1973.sp010244.
4
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Prog Biophys Mol Biol. 1973;26:1-43. doi: 10.1016/0079-6107(73)90016-3.
5
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