利用生理胰岛素水平对人二倍体成纤维细胞上胰岛素受体进行化学计量结合与调节。 - Suppr

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超能文献

Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels.

作者信息

Mott D M, Howard B V, Bennett P H

出版信息

J Biol Chem. 1979 Sep 25;254(18):8762-7.

PMID:479155

Abstract

摘要

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Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels.利用生理胰岛素水平对人二倍体成纤维细胞上胰岛素受体进行化学计量结合与调节。

J Biol Chem. 1979 Sep 25;254(18):8762-7.

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Diabetes. 1981 Nov;30(11):940-6. doi: 10.2337/diab.30.11.940.

Fibroblasts from a leprechaun patient have defects in insulin binding and insulin receptor autophosphorylation.妖精貌综合征患者的成纤维细胞在胰岛素结合和胰岛素受体自身磷酸化方面存在缺陷。

Diabetologia. 1988 Aug;31(8):612-7. doi: 10.1007/BF00264769.

Regulation of insulin receptors in cultured human fibroblasts.

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Effect of temperature on insulin binding and action in cultured human fibroblasts.温度对培养的人成纤维细胞中胰岛素结合及作用的影响。

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Primary defect of insulin receptors in skin fibroblasts cultured from an infant with leprechaunism and insulin resistance.从一名患脂肪代谢障碍和胰岛素抵抗的婴儿培养的皮肤成纤维细胞中胰岛素受体的原发性缺陷。

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Fibroblastic cultures from the diabetic db/db mouse. Demonstration of decreased insulin receptors and impaired responses to insulin.来自糖尿病db/db小鼠的成纤维细胞培养物。胰岛素受体减少及对胰岛素反应受损的证明。

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Mitogen receptors in chick embryo fibroblasts. Kinetics, specificity, unmasking, and synthesis of 125I-insulin binding sites.鸡胚成纤维细胞中的促有丝分裂原受体。125I-胰岛素结合位点的动力学、特异性、暴露及合成

J Biol Chem. 1976 Oct 25;251(20):6445-55.

Demonstration of a primary (? genetic) defect in insulin receptors in fibroblasts from a patient with the syndrome of insulin resistance and acanthosis nigricans type A.一名患有A型胰岛素抵抗和黑棘皮症综合征患者的成纤维细胞中胰岛素受体原发性（可能为遗传性）缺陷的证明。

J Clin Endocrinol Metab. 1980 Jun;50(6):1139-41. doi: 10.1210/jcem-50-6-1139.

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Internalization and molecular processing of insulin receptors in isolated rat adipocytes.分离的大鼠脂肪细胞中胰岛素受体的内化及分子加工

Proc Natl Acad Sci U S A. 1982 Jul;79(13):4069-73. doi: 10.1073/pnas.79.13.4069.

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes.胰岛素诱导大鼠脂肪细胞中胰岛素受体内化和降解的证据。

Proc Natl Acad Sci U S A. 1982 Jan;79(2):427-31. doi: 10.1073/pnas.79.2.427.

Glucocorticoid-induced insulin resistance: the importance of postbinding events in the regulation of insulin binding, action, and degradation in freshly isolated and primary cultures of rat hepatocytes.糖皮质激素诱导的胰岛素抵抗：结合后事件在大鼠肝细胞新鲜分离物及原代培养物中胰岛素结合、作用和降解调节中的重要性。

J Clin Invest. 1982 Apr;69(4):866-75. doi: 10.1172/jci110526.

Stimulation of glucose incorporation and amino acid transport by insulin and an insulin-like growth factor in fibroblasts with defective insulin receptors cultured from a patient with leprechaunism.来自一名妖精貌综合征患者的胰岛素受体缺陷型成纤维细胞中，胰岛素和一种胰岛素样生长因子对葡萄糖掺入及氨基酸转运的刺激作用。

Proc Natl Acad Sci U S A. 1981 Apr;78(4):2554-8. doi: 10.1073/pnas.78.4.2554.

Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level.胰岛素孵育对分离的大鼠脂肪细胞胰岛素结合、葡萄糖转运及胰岛素降解的影响。激素诱导受体及受体后水平脱敏的证据。

J Clin Invest. 1980 Oct;66(4):763-72. doi: 10.1172/JCI109914.

Studies of the transferrin receptor on both human reticulocytes and nucleated human cells in culture: comparison of factors regulating receptor density.人网织红细胞和培养的有核人细胞中转铁蛋白受体的研究：调节受体密度的因素比较

J Clin Invest. 1982 Apr;69(4):853-65. doi: 10.1172/jci110525.

Direct in vitro effect of a sulfonylurea to increase human fibroblast insulin receptors.一种磺脲类药物增加人成纤维细胞胰岛素受体的直接体外效应。

J Clin Invest. 1980 Sep;66(3):608-11. doi: 10.1172/JCI109894.

Insulin binding in cultured Chinese hamster kidney epithelial cells: the effect of serum in the medium.培养的中国仓鼠肾上皮细胞中的胰岛素结合：培养基中血清的影响。

In Vitro. 1982 Mar;18(3 Pt 1):243-50. doi: 10.1007/BF02618577.

Binding and molecular weight properties of the insulin receptor from omental and subcutaneous adipocytes in human obesity.人类肥胖症中网膜和皮下脂肪细胞胰岛素受体的结合特性及分子量特性

Diabetologia. 1984 Oct;27(4):447-53. doi: 10.1007/BF00273909.

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