McKenna G, Bradley G W, Dunn H K, Statton W O
J Biomed Mater Res. 1979 Sep;13(5):783-98. doi: 10.1002/jbm.820130509.
The degradation resistance of matrix, fiber and composite systems which we have been studying as candidate orthopedic materials has been examined in two appropriate environments. Both resistance to steam sterilization in an autoclave environment and resistance to a simulated physiologic solution have been studied. In the autoclave study, samples were placed in a pressure cooker at 123 degrees C for differing amounts of time and tested for retention of mechanical properties. Results indicate that most of the materials tested could be autoclaved several times, as long as autoclave times did not exceed 1 hr. Longer autoclave times result in an accelerated degradation and loss of strength of all materials except the polypropylene. Polysulfone degrades after even the shortest autoclave duration. Resistance to the simulated physiologic environment was tested by measured retention of mechanical properties after immersion times in pseudo-extracellular fluid (PECF) at 37 degrees C for as long as three years. None of the materials showed any significant changes in properties after immersion in the PECF.
我们一直在研究作为候选骨科材料的基体、纤维及复合材料系统在两种合适环境中的抗降解性。研究了在高压釜环境下对蒸汽灭菌的抗性以及对模拟生理溶液的抗性。在高压釜研究中，将样品置于123摄氏度的压力锅中不同时间，然后测试其力学性能的保持情况。结果表明，只要高压釜时间不超过1小时，大多数测试材料都可以进行多次高压灭菌。较长的高压釜时间会导致除聚丙烯外的所有材料加速降解和强度损失。即使是最短的高压釜持续时间后，聚砜也会降解。通过在37摄氏度的伪细胞外液（PECF）中浸泡长达三年后测量力学性能的保持情况来测试对模拟生理环境的抗性。在PECF中浸泡后，没有一种材料的性能显示出任何显著变化。
