Luyx A, De Hertogh R, Foldesi A, Rousseau P
J Gynecol Obstet Biol Reprod (Paris). 1979 Mar;8(2):131-6.
53 cases of pregnancy complicated by bleeding between the 7th and 16th week have been studied by repeated estimations of non-conjugated plasma oestradiol and oestriol carried out at the same time as ultrasound morphological measurements were performed. 24 pregnancies went on to term while 29 met with the loss of the fetus. In each case where the outcome was favourable the plasma oestriol and oestradiol levels were comparable to those found in 95 control pregnant women whose pregnancies progressed normally. In 26 cases where the outcome was unfavourable the levels were too low and corresponded to an ultrasound picture that was abnormal or revealed absence of heart beat. In 3 cases the first levels of oestradiol and oestriol seemed to be normal. Later, when failure of growth of the embryo and absence of heart beat were found, a considerable drop in the levels of oestradiol and of oestriol in the blood was also revealed. This study shows a good correlation between hormone levels and ultrasound findings in pregnancies complicated by bleeding. All the same, the prognostic value of hormone measurements as compared with ultrasound measurements has not yet been established, and needs analysis of a far greater number of cases of a similar type.
对53例妊娠第7至16周并发出血的病例进行了研究，在进行超声形态学测量的同时，反复测定非结合血浆雌二醇和雌三醇。24例妊娠至足月，29例胎儿丢失。在每一例结局良好的病例中，血浆雌三醇和雌二醇水平与95例正常妊娠的对照孕妇相当。在26例结局不良的病例中，这些水平过低，对应于异常的超声图像或显示无心跳。3例中，最初的雌二醇和雌三醇水平似乎正常。后来，当发现胚胎生长停止和无心跳时，血液中雌二醇和雌三醇水平也出现了显著下降。这项研究表明，在妊娠并发出血的情况下，激素水平与超声检查结果之间存在良好的相关性。尽管如此，与超声测量相比，激素测量的预后价值尚未确定，需要对大量类似类型的病例进行分析。
