噬菌体T4中的热诱变：转变途径。
Heat mutagenesis in bacteriophage T4: the transition pathway.
作者信息
Baltz R H, Bingham P M, Drake J W
出版信息
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1269-73. doi: 10.1073/pnas.73.4.1269.
Abstract
G-C leads to A-T transitions are induced by heat, and arise from the deamination of cytosine (5-hydroxymethylcytosine in the case of bacteriophage T4) generating uracil. The reaction is proton-catalyzed, and is also characteristic of acid mutagenesis. Mutation rates and activation energies of mutation are site-specific, and are presumably influenced by neighboring bases. Rates of heat-induced mutation in bacteriophage T4 under conditions of temperature, pH, and ionic strength similar to those prevailing in higher eukaryotic cells suggest that heat mutagenesis may present a serious challenge to organisms with large genomes, and may comprise an important determinant of the rates of spontaneous mutation.
摘要
由热诱导的G-C到A-T的转变，源于胞嘧啶（噬菌体T4的情况下为5-羟甲基胞嘧啶）脱氨生成尿嘧啶。该反应由质子催化，也是酸致突变的特征。突变率和突变活化能具有位点特异性，可能受相邻碱基的影响。在与高等真核细胞中相似的温度、pH和离子强度条件下，噬菌体T4的热诱导突变率表明，热诱变可能对具有大基因组的生物体构成严峻挑战，并且可能是自发突变率的一个重要决定因素。
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