噬菌体T4中的热诱变：颠换途径。
Heat mutagenesis in bacteriophage T4: the transversion pathway.
作者信息
Bingham P M, Baltz R H, Ripley L S, Drake J W
出版信息
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4159-63. doi: 10.1073/pnas.73.11.4159.
Abstract
Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.
摘要
热诱导噬菌体T4中G-C碱基对发生颠换（以及转换）。颠换的靶碱基是鸟嘌呤，它会转化为一种产物，该产物有时会作为嘧啶进行复制和转录。为此过程提出了一个模型，其中脱氧鸟苷糖苷键从N9迁移到N2：由此产生的脱氧新鸟苷可能与正常鸟嘌呤配对，从而产生G-C导致C-G颠换。
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