致癌物3-甲基胆蒽与仓鼠成纤维细胞脱氧核糖核酸的嘌呤和嘧啶碱基结合的证据。
Evidence for the binding of the carcinogen 3-methylcholanthrene to both the purine and the pyrimidine bases of hamster fibroblast deoxyribonucleic acid.
作者信息
Jones P A, Gevers W, Hawtrey A O
出版信息
Biochem J. 1973 Oct;135(2):375-8. doi: 10.1042/bj1350375.
Abstract
The binding of [(3)H]3-methylcholanthrene to the DNA of hamster fibroblasts was studied by using chemical methods for DNA degradation. DNA depurinated by mild acid hydrolysis released approximately half of the radioactivity at the same rate as the purine bases, but the resulting apurinic acid still contained radioactive carcinogen.
摘要
通过使用化学方法降解DNA，研究了[（3）H] 3-甲基胆蒽与仓鼠成纤维细胞DNA的结合。经温和酸水解脱嘌呤的DNA以与嘌呤碱基相同的速率释放出约一半的放射性，但所得的脱嘌呤酸仍含有放射性致癌物。
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本文引用的文献
1
The formation apurinic acid from the desoxyribonucleic acid of calf thymus.由小牛胸腺脱氧核糖核酸形成脱嘌呤酸。
J Biol Chem. 1952 Mar;195(1):49-63.
2
STUDIES ON THE NUCLEOTIDE ARRANGEMENT IN DEOXYRIBONUCLEIC ACIDS. 8. A COMPARISON OF PROCEDURES FOR THE DETERMINATION OF THE FREQUENCY OF PYRIMIDINE NUCLEOTIDE RUNS.脱氧核糖核酸中核苷酸排列的研究。8. 嘧啶核苷酸连续序列频率测定方法的比较
Biochim Biophys Acta. 1964 Oct 16;91:262-70. doi: 10.1016/0926-6550(64)90250-6.
3
4
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
J Exp Med. 1954 Feb;99(2):167-82. doi: 10.1084/jem.99.2.167.
5
In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.致癌碳氢化合物使正常细胞在体外转化为肿瘤细胞。
J Natl Cancer Inst. 1965 Oct;35(4):641-61.
6
A microsome-dependent binding of benzo[a]pyrene to DNA.微粒体介导的苯并[a]芘与DNA的结合。
Cancer Res. 1969 Jun;29(6):1272-6.
7
The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture.多环芳烃与培养中的可转化细胞的DNA、RNA及蛋白质的结合。
Cancer Res. 1971 Dec;31(12):2168-76.
8
Structure and activity in chemical carcinogenesis. Studies of variously substituted 7-bromomethylbenz(a)anthracenes.化学致癌作用中的结构与活性。对各种取代的7-溴甲基苯并(a)蒽的研究。
Eur J Cancer (1965). 1971 Oct;7(5):473-6. doi: 10.1016/0014-2964(71)90046-6.
9
10
Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.化学物质致癌作用概述——G. H. A. 克劳斯纪念讲座
Cancer Res. 1970 Mar;30(3):559-76.
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