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致癌物3-甲基胆蒽与仓鼠成纤维细胞脱氧核糖核酸的嘌呤和嘧啶碱基结合的证据。

Evidence for the binding of the carcinogen 3-methylcholanthrene to both the purine and the pyrimidine bases of hamster fibroblast deoxyribonucleic acid.

作者信息

Jones P A, Gevers W, Hawtrey A O

出版信息

Biochem J. 1973 Oct;135(2):375-8. doi: 10.1042/bj1350375.

DOI:10.1042/bj1350375
PMID:4797167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1165833/
Abstract

The binding of [(3)H]3-methylcholanthrene to the DNA of hamster fibroblasts was studied by using chemical methods for DNA degradation. DNA depurinated by mild acid hydrolysis released approximately half of the radioactivity at the same rate as the purine bases, but the resulting apurinic acid still contained radioactive carcinogen.

摘要

通过使用化学方法降解DNA，研究了[（3）H] 3-甲基胆蒽与仓鼠成纤维细胞DNA的结合。经温和酸水解脱嘌呤的DNA以与嘌呤碱基相同的速率释放出约一半的放射性，但所得的脱嘌呤酸仍含有放射性致癌物。

相似文献

1
Evidence for the binding of the carcinogen 3-methylcholanthrene to both the purine and the pyrimidine bases of hamster fibroblast deoxyribonucleic acid.致癌物3-甲基胆蒽与仓鼠成纤维细胞脱氧核糖核酸的嘌呤和嘧啶碱基结合的证据。
Biochem J. 1973 Oct;135(2):375-8. doi: 10.1042/bj1350375.
2
DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites.来自培养的人成纤维细胞的DNA结合活性，该活性对部分脱嘌呤的DNA具有特异性，并能将嘌呤插入无嘌呤位点。
Proc Natl Acad Sci U S A. 1979 Jan;76(1):141-4. doi: 10.1073/pnas.76.1.141.
3
[Purine and pyrimidine bases entering the composition of DNA and RNA studied by gas-liquid chromatography].
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Further characterization of a depurinated DNA-purine base insertion activity from cultured human fibroblasts.对培养的人成纤维细胞中脱嘌呤DNA-嘌呤碱基插入活性的进一步表征。
J Biol Chem. 1979 Dec 10;254(23):12099-103.
5
Autoradiographic demonstration of H-3-methylcholanthrene labeling of nuclear components of Syrian hamster cells in vitro.体外叙利亚仓鼠细胞核成分的H-3-甲基胆蒽标记的放射自显影证明。
Proc Natl Acad Sci U S A. 1967 Jul;58(1):123-6. doi: 10.1073/pnas.58.1.123.
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Stimulation of astrocyte proliferation by purine and pyrimidine nucleotides and nucleosides.嘌呤和嘧啶核苷酸及核苷对星形胶质细胞增殖的刺激作用。
Glia. 1993 Feb;7(2):176-82. doi: 10.1002/glia.440070207.
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Extracellular purine and pyrimidine catabolism in cell culture.细胞培养中的细胞外嘌呤和嘧啶分解代谢。
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[Determination of purine and pyrimidine derivatives in acid-soluble fractions of organs and tissues using high-performance reverse-phase ion-pair chromatography].[使用高效反相离子对色谱法测定器官和组织酸溶性部分中的嘌呤和嘧啶衍生物]
Vopr Med Khim. 1987 Jan-Feb;33(1):133-8.
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[The assimilation by Eimeria tenella coccidia of DNA and RNA precursors from the host cell].[柔嫩艾美耳球虫对宿主细胞DNA和RNA前体的同化作用]
Parazitologiia. 1979 Jan-Feb;13(1):82-3.

本文引用的文献

1
The formation apurinic acid from the desoxyribonucleic acid of calf thymus.由小牛胸腺脱氧核糖核酸形成脱嘌呤酸。
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2
STUDIES ON THE NUCLEOTIDE ARRANGEMENT IN DEOXYRIBONUCLEIC ACIDS. 8. A COMPARISON OF PROCEDURES FOR THE DETERMINATION OF THE FREQUENCY OF PYRIMIDINE NUCLEOTIDE RUNS.脱氧核糖核酸中核苷酸排列的研究。8. 嘧啶核苷酸连续序列频率测定方法的比较
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EVIDENCE FOR THE BINDING OF POLYNUCLEAR AROMATIC HYDROCARBONS TO THE NUCLEIC ACIDS OF MOUSE SKIN: RELATION BETWEEN CARCINOGENIC POWER OF HYDROCARBONS AND THEIR BINDING TO DEOXYRIBONUCLEIC ACID.多环芳烃与小鼠皮肤核酸结合的证据：烃类致癌能力与其与脱氧核糖核酸结合之间的关系。
Nature. 1964 May 23;202:781-4. doi: 10.1038/202781a0.
4
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
J Exp Med. 1954 Feb;99(2):167-82. doi: 10.1084/jem.99.2.167.
5
In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.致癌碳氢化合物使正常细胞在体外转化为肿瘤细胞。
J Natl Cancer Inst. 1965 Oct;35(4):641-61.
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A microsome-dependent binding of benzo[a]pyrene to DNA.微粒体介导的苯并[a]芘与DNA的结合。
Cancer Res. 1969 Jun;29(6):1272-6.
7
The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture.多环芳烃与培养中的可转化细胞的DNA、RNA及蛋白质的结合。
Cancer Res. 1971 Dec;31(12):2168-76.
8
Structure and activity in chemical carcinogenesis. Studies of variously substituted 7-bromomethylbenz(a)anthracenes.化学致癌作用中的结构与活性。对各种取代的7-溴甲基苯并(a)蒽的研究。
Eur J Cancer (1965). 1971 Oct;7(5):473-6. doi: 10.1016/0014-2964(71)90046-6.
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Isolation and degradation of DNA from cells treated with tritium-labeled 7,12-dimethylbenz(a)anthracene: studies on the nature of the binding of this carcinogen to DNA.
Cancer Res. 1969 Jan;29(1):157-65.
10
Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.化学物质致癌作用概述——G. H. A. 克劳斯纪念讲座
Cancer Res. 1970 Mar;30(3):559-76.